Rs266729
| is a | snp |
| is | mentioned by |
| dbSNP | rs266729 |
| nextbio | rs266729 |
| hapmap | rs266729 |
| 1000 genomes | rs266729 |
| hgdp | rs266729 |
| ensembl | rs266729 |
| gopubmed | rs266729 |
| scholar | rs266729 |
| rs266729 | |
| pharmgkb | rs266729 |
| gwascentral | rs266729 |
| openSNP | rs266729 |
| 23andMe | rs266729 |
| 23andMe all | rs266729 |
| SNP Nexus | |
| SNPshot | rs266729 |
| SNPdbe | rs266729 |
| MSV3d | rs266729 |
| Gene | ADIPOQ |
| Chromosome | 3 |
| Orientation | plus |
| Position | 186559474 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 0 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;G) | 0.73x decreased risk for colorectal cancer | |
| (G;G) | 0.73x decreased risk for colorectal cancer |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
Two case-control studies including colorectal cancer patients and controls were conducted; the first case involving 441 patients and 658 controls, all of Ashkenazi Jewish ancestry, and the second including 199 patients and 199 matched (sex, age and ethnicity) controls.
rs266729(G) showed decreased colorectal cancer risk in both studies; in the first, with an odds ratio of 0.72 (CI:0.55-0.95) and in the second, with an odds ratio of 0.52 (CI: 0.34-0.78). Combining the two studies led to an overall decreased colorectal cancer odds ratio of 0.73 (CI: 0.53-0.99) for this allele.[1]
spittoon obesity and colorectal cancer (G;G) 27% lower odds [PMID 18827209]
[PMID 19264763] Common variation at the Adiponectin locus is not associated with colorectal cancer risk in the United Kingdom
[PMID 19273568] Genetic variation in adipokine genes and risk of colorectal cancer
[PMID 19359061] APM1 gene variants -11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes
| OMIM | 612556 |
| Desc | ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1; ADIPQTL1 |
| Variant | |
| Related | also |
| PharmGKB | PA162355886 |
| Name | |
| Annotation | In two case-control studies this SNP in the 5' UTR of the ADIPOQ gene was associated with decreased colorectal cancer risk. |
| Gene | ADIPOQ |
| Featue | |
| Evidence | PubMed ID:18827209 |
| Drugs | |
| Diseases | Colorectal Neoplasms |
| Curation Level | Curated |
[PMID 20516205] Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese
[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population
[PMID 21208676] Association of the adiponectin rs266729 C>G variant and coronary heart disease in the low risk 'Golden Years' type 1 diabetes cohort
[PMID 21248784] Common variation in the adiponectin gene has an effect on systolic blood pressure
[PMID 21397927] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk
[PMID 21619462] The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer
[PMID 21637408] A lack of association between adiponectin polymorphisms and coronary artery disease in a Chinese population
[PMID 21829206] Adiponectin gene and risk of colorectal cancer
[PMID 21960694] Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer
