Rs25489

rs25489, a SNP also known as Arg280His located in the DNA-repair gene XRCC1, is associated with an increased risk for breast cancer based on a study of 1,100 Cypriot women. The odds ratio for the rs25489(A;A) homozygote is 4.68, CI: 1.01-21.7, p=0.03.[PMID 18188695]

rs25489(A;G) prostate cancer patients being treated by radiation therapy are more likely (67% compared to 24%, p=0.048) to develop erectile dysfunction after irradiation than (G;G) patients, based on a study of 135 patients.[PMID 18582155]

[PMID 21216841] A meta-analysis concludes that this SNP is not associated with risk of gastric cancer.

[PMID 17767850] Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer: a case-control study

[PMID 19707910] Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis

[PMID 21419115] DNA Repair Gene ERCC2 Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck