Rs242557

A case-control study of 300 patients with Alzheimer's disease found that subjects carrying both the rs2071746(T;T) and rs242557(A;A) genotypes had a 6.65x increased risk (CI: 1.12-39.29; p = 0.037) compared to subjects without these risk genotypes. [PMID 18841019] This combination of SNPs was formerly listed as the gs124 genoset, which was dropped from SNPedia.

[PMID 19308965] Reports that they found only "nominally significant" association between Alzheimer's and rs242557 in ApoE4 positive individuals.

[PMID 19912324] Association of the MAPT locus with Parkinson's disease

[PMID 20951764] High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal ?-amyloid in Parkinson disease

GWAS snp
PMID	[PMID 21685912]
Trait
Title	Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
Risk Allele
P-val	9E-18
Odds Ratio	1.4300 [1.32-1.54]