Rs2383207
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs2383207 |
| hapmap | rs2383207 |
| hgdp | rs2383207 |
| ensembl | rs2383207 |
| gopubmed | rs2383207 |
| scholar | rs2383207 |
| rs2383207 | |
| pharmgkb | rs2383207 |
| hgvbaseg2p | rs2383207 |
| medrefsnp | rs2383207 |
| 23andMe | rs2383207 |
| SNP Nexus |
| Chromosome | 9 |
| Orientation | plus |
| Position | 22105958 |
| Genotype | Effect |
|---|---|
| rs2383207(A;A) | normal |
| rs2383207(A;G) | increased risk for heart disease |
| rs2383207(G;G) | increased risk for heart disease |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs2383207(A;A) | 00 | normal |
| Rs2383207(A;G) | 22 | increased risk for heart disease |
| Rs2383207(G;G) | 2.12.1 | increased risk for heart disease |
[PMID 18048766] This SNP was also associated with increased risk for coronary artery disease in a Korean population.
The association remained significant after adjusting for significant clinical covariates (P=0.001 to 0.024). We identified one risk haplotype (GGGG; P=0.017) and one protective haplotype (AAAA; P=0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P=0.001 to 0.024; OR=2.37 to 1.54).
[PMID 18066490] Also found to be significant in a study of 416 Italian myocardial infarction patients.
[PMID 18757290] Found to be associated with coronary heart disease in a study of 1360 Chinese Han patients, with an odds ratio of 1.52 (CI: 1.13 - 2.04) for rs2383207(G;G) individuals. This risk was magnified in subjects who were males, less than 60 years old, overweight, or smokers.
| Neighbor | rs2383206 |
| Distance | 933 |
| ? | (A;A) (A;G) (G;G) |
|---|---|
|
| |
[PMID 19293724] The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension
[PMID 19901189] A Common Variant at 9p21 Is Associated With Sudden and Arrhythmic Cardiac Death
[PMID 20031580] Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study
