Rs2383207
| Orientation | plus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2383207 |
| PheGenI | rs2383207 |
| nextbio | rs2383207 |
| hapmap | rs2383207 |
| 1000 genomes | rs2383207 |
| hgdp | rs2383207 |
| ensembl | rs2383207 |
| gopubmed | rs2383207 |
| geneview | rs2383207 |
| scholar | rs2383207 |
| rs2383207 | |
| pharmgkb | rs2383207 |
| gwascentral | rs2383207 |
| openSNP | rs2383207 |
| 23andMe | rs2383207 |
| 23andMe all | rs2383207 |
| SNP Nexus | |
| SNPshot | rs2383207 |
| SNPdbe | rs2383207 |
| MSV3d | rs2383207 |
| Gene | CDKN2B-AS1 |
| Chromosome | 9 |
| Orientation | plus |
| GMAF | 0.3324 |
| Position | 22115959 |
| Reference | GRCh37.p5 37.3/137 |
| Max Magnitude | 2.1 |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal |
| (A;G) | 2 | increased risk for heart disease |
| (G;G) | 2.1 | increased risk for heart disease |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
[PMID 18048766] This SNP was also associated with increased risk for coronary artery disease in a Korean population.
The association remained significant after adjusting for significant clinical covariates (P=0.001 to 0.024). We identified one risk haplotype (GGGG; P=0.017) and one protective haplotype (AAAA; P=0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P=0.001 to 0.024; OR=2.37 to 1.54).
[PMID 18066490] Also found to be significant in a study of 416 Italian myocardial infarction patients.
[PMID 18757290] Found to be associated with coronary heart disease in a study of 1360 Chinese Han patients, with an odds ratio of 1.52 (CI: 1.13 - 2.04) for rs2383207(G;G) individuals. This risk was magnified in subjects who were males, less than 60 years old, overweight, or smokers.
| Neighbor | rs2383206 |
| Distance | 933 |
[PMID 19293724] The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension
[PMID 19901189] A Common Variant at 9p21 Is Associated With Sudden and Arrhythmic Cardiac Death
[PMID 20031580] Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study
| GWAS snp | |
|---|---|
| PMID | [PMID 20622881] |
| Trait | Abdominal aortic aneurysm |
| Title | Genome-wide association study identifies a sequence variant with the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |
| Risk Allele | G |
| P-val | 2E-8 |
| Odds Ratio | 1.27 [NR] |
[PMID 21152093] Sex Differential Genetic Effect of Chromosome 9p21 on Subclinical Atherosclerosis
[PMID 22122968] Additive Effect of ANRIL and BRAP Polymorphisms on Ankle-Brachial Index in a Taiwanese Population
[PMID 21385355] Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry
[PMID 18362232] Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.
[PMID 18459066] A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease.
[PMID 18505420] Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).
[PMID 18620593] Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome.
[PMID 18704761] Molecular genetics of myocardial infarction.
[PMID 18987759] Genetic testing for atherosclerosis risk: inevitability or pipe dream?
[PMID 19173706] The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis.
[PMID 19463184] Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.
[PMID 19475673] Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke.
[PMID 19819472] Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery.
[PMID 19888323] Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants.
[PMID 19956784] Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease.
[PMID 20386740] Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.
[PMID 20718794] Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS.
[PMID 20858033] Haplotypes on 9p21 modify the risk for coronary artery disease among Indians.
[PMID 21415773] Chromosome 9p21 genetic variants are associated with myocardial infarction but not with ischemic stroke in a Taiwanese population.
[PMID 23343465] Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
[PMID 23535969] Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome
