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Rs2383207

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Orientationplus
is asnp
is mentioned by
dbSNPrs2383207
PheGenIrs2383207
hapmaprs2383207
1000 genomesrs2383207
hgdprs2383207
ensemblrs2383207
gopubmedrs2383207
geneviewrs2383207
scholarrs2383207
googlers2383207
pharmgkbrs2383207
gwascentralrs2383207
openSNPrs2383207
23andMers2383207
23andMe allrs2383207
SNP Nexus

SNPshotrs2383207
SNPdbers2383207
MSV3drs2383207
GeneCDKN2B-AS1
Chromosome9
Orientationplus
GMAF0.3324
Position22115960
ReferenceGRCh38 38.1/141
Max Magnitude2.1
Geno Mag Summary
(A;A) 0 normal
(A;G) 2 increased risk for heart disease
(G;G) 2.1 increased risk for heart disease
? (A;A) (A;G) (G;G) 28
discussed in this blog post as possibly playing a role in coronary heart disease

[PMID 18048766] This SNP was also associated with increased risk for coronary artery disease in a Korean population.

The association remained significant after adjusting for significant clinical covariates (P=0.001 to 0.024). We identified one risk haplotype (GGGG; P=0.017) and one protective haplotype (AAAA; P=0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P=0.001 to 0.024; OR=2.37 to 1.54).

[PMID 18066490] Also found to be significant in a study of 416 Italian myocardial infarction patients.

[PMID 18757290] Found to be associated with coronary heart disease in a study of 1360 Chinese Han patients, with an odds ratio of 1.52 (CI: 1.13 - 2.04) for rs2383207(G;G) individuals. This risk was magnified in subjects who were males, less than 60 years old, overweight, or smokers.

Neighborrs2383206
Distance933
OMIM611139
DescCORONARY HEART DISEASE, SUSCEPTIBILITY TO, 8; CHDS8
Variant
Relatedalso

[PMID 19293724] The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension

[PMID 19901189OA-icon.png] A Common Variant at 9p21 Is Associated With Sudden and Arrhythmic Cardiac Death


[PMID 20031580] Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study

GWAS snp
PMID [PMID 20622881]
Trait Abdominal aortic aneurysm
Title Genome-wide association study identifies a sequence variant with the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
Risk Allele G
P-val 2E-8
Odds Ratio 1.27 [NR]

[PMID 21152093OA-icon.png] Sex Differential Genetic Effect of Chromosome 9p21 on Subclinical Atherosclerosis


[PMID 22122968] Additive Effect of ANRIL and BRAP Polymorphisms on Ankle-Brachial Index in a Taiwanese Population


[PMID 21385355OA-icon.png] Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry


[PMID 18362232OA-icon.png] Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.


[PMID 18459066] A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease.


[PMID 18505420OA-icon.png] Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).


[PMID 18620593OA-icon.png] Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome.


[PMID 18704761OA-icon.png] Molecular genetics of myocardial infarction.


[PMID 18987759OA-icon.png] Genetic testing for atherosclerosis risk: inevitability or pipe dream?


[PMID 19173706OA-icon.png] The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis.


[PMID 19463184OA-icon.png] Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.


[PMID 19475673OA-icon.png] Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke.


[PMID 19819472OA-icon.png] Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery.


[PMID 19888323OA-icon.png] Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants.


[PMID 19956784OA-icon.png] Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease.


[PMID 20386740OA-icon.png] Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.


[PMID 20718794] Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS.


[PMID 20858033] Haplotypes on 9p21 modify the risk for coronary artery disease among Indians.


[PMID 21415773] Chromosome 9p21 genetic variants are associated with myocardial infarction but not with ischemic stroke in a Taiwanese population.


[PMID 23343465OA-icon.png] Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes


[PMID 23535969] Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome


[PMID 22882272OA-icon.png] Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke.


[PMID 22975211] Meta-analysis of genetic association of chromosome 9p21 with early-onset coronary artery disease.