From SNPedia
rs10757274 and
rs2383206 can double the risk of
heart disease[1]. About one in every four Caucasians are thought to carry the gene variants.
rs10757278 in the same region has been linked to
diabetes [2]
a blog post about investigating rs10757274 and rs2383206
[PMID 18048766] This SNP was also associated with increased risk for coronary artery disease in a Korean population.
[PMID 18066490] Also found to be significant in a study of 416 Italian myocardial infarction patients.
A study of 1,000+ patients with early-onset angiographic coronary artery disease (CAD) concluded that rs2383206(G) was associated with an adjusted odds ratio of 1.39 (CI: 1.05-1.85) for (A;G) heterozygotes and 1.73 (CI: 1.26-2.37) for (G;G) homozygotes. This SNP alone accounted for 21% of the population attributable fraction and was independent of traditional risk factors, myocardial infarction risk, and the extent of disease.[PMID 19033013]
| ? | (A;A) (A;G) (G;G) |
|---|
 |
Related to CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 8; CHDS8
according to
omim 611139. See
also
[PMID 19559344] Genetic variants on chromosome 9p21 and ischemic stroke in Chinese
[PMID 20031605] 9p21 is a Shared Susceptibility Locus Strongly for Coronary Artery Disease and Weakly for Ischemic Stroke in Chinese Han Population
