Rs2383206

rs10757274 and rs2383206 can double the risk of heart disease[1]. About one in every four Caucasians are thought to carry the gene variants. rs10757278 in the same region has been linked to diabetes [2]

a blog post about investigating rs10757274 and rs2383206

[PMID 18048766] This SNP was also associated with increased risk for coronary artery disease in a Korean population.

[PMID 18066490] Also found to be significant in a study of 416 Italian myocardial infarction patients.

A study of 1,000+ patients with early-onset angiographic coronary artery disease (CAD) concluded that rs2383206(G) was associated with an adjusted odds ratio of 1.39 (CI: 1.05-1.85) for (A;G) heterozygotes and 1.73 (CI: 1.26-2.37) for (G;G) homozygotes. This SNP alone accounted for 21% of the population attributable fraction and was independent of traditional risk factors, myocardial infarction risk, and the extent of disease.[PMID 19033013]

[PMID 19559344] Genetic variants on chromosome 9p21 and ischemic stroke in Chinese

[PMID 20031605] 9p21 is a Shared Susceptibility Locus Strongly for Coronary Artery Disease and Weakly for Ischemic Stroke in Chinese Han Population

[PMID 21375403] The Relationship Between Polymorphisms on Chromosome 9p21 and Age of Onset of Coronary Heart Disease in Black and White Women

[PMID 20718794] Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS

[PMID 21385355] Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry