From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
normal
|
| (A;G)
|
|
0.67x decreased risk for lung cancer
|
| (G;G)
|
|
0.10x decreased risk for lung cancer
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
, also known as K178R, is a SNP in the
MGMT gene. The more common allele,
rs2308327(A), encodes a lysine (K) at codon 178, while the (G) allele encodes an arginine (R).
In a pooled analysis of 200+ lung cancer patients, the rs2308327(G) allele was reported to provide a protective effect against lung cancer, and furthermore, more (G) alleles meant more protection, particularly for smokers. The odds ratios reported (p=0.003) were 0.67 (CI: 0.45-1.01) for heterozygotes, and 0.10 (CI: 0.01-0.94) for rs2308327(G;G) homozygotes.[PMID 17957803]
In a study of 300+ colon cancer cases, rs2308327(G), in linkage disequilibrium with the previously reported MGMT Ile(143)Val rs2308321 SNP, had an inverse association with colorectal cancer risk (odds ratio 0.52, CI: 0.35-0.78, unadjusted p(trend) = 0.0003 for the additive model).[PMID 18268114]
[PMID 20938339] Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients
