Rs2301436

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Increased risk for Crohn's disease
Orientationminus
Geno Mag Summary
(A;A) 2.1
(G;G) 0
Make rs2301436(A;G)
ReferenceGRCh38 38.1/141
Chromosome6
Position167024500
GeneFGFR1OP
is asnp
is mentioned by
dbSNPrs2301436
Exacrs2301436
PheGenIrs2301436
nextbiors2301436
hapmaprs2301436
1000 genomesrs2301436
hgdprs2301436
ensemblrs2301436
gopubmedrs2301436
geneviewrs2301436
scholarrs2301436
googlers2301436
pharmgkbrs2301436
gwascentralrs2301436
openSNPrs2301436
23andMers2301436
23andMe allrs2301436
SNP Nexus

SNPshotrs2301436
SNPdbers2301436
MSV3drs2301436
GMAF0.3875
? (A;A) (A;G) (G;G) 28
GWAS
SNP rs2301436
PubMedID [PMID 18587394OA-icon.png]
Condition Crohn's disease
Gene CCR6
Risk Allele T
pValue 1.00E-012
OR 1.21
95% CI



GWAS snp
PMID [PMID 20570966OA-icon.png]
Trait Crohn's disease
Title Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease
Risk Allele
P-val 6E-8
Odds Ratio 1.37 [1.22-1.53]

DeCode reports that rs2301436 is associated with susceptibility to Crohn's disease. [PMID 18587394OA-icon.png]


[PMID 22269120] Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease


[PMID 19557189OA-icon.png] Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.


[PMID 20018022OA-icon.png] Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.


[PMID 21304891OA-icon.png] A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.


[PMID 21304977OA-icon.png] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.


[PMID 21763254] Polymorphisms in CCR6 are associated with chronic graft-versus-host disease and invasive fungal disease in matched-related hematopoietic stem cell transplantation.


[PMID 21873313] There is no association of CCR6 polymorphisms with susceptibility to Behcet's disease in two Chinese Han populations.


GET Evidence
rs2301436
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.420635
summary



[PMID 22922229OA-icon.png] Seven newly identified loci for autoimmune thyroid disease.