From SNPedia
rs2298566 is a SNP in the MYH15 gene. The risk allele in terms of heart disease is rs2298566(C).
This SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD).
For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.[PMID 18073581]
| ? | (A;C) (C;C) |
|---|
 |
| PharmGKB | PA161795947 |
| Name | |
| Annotation | This variant is associated with an elevated risk of coronary heart diseases. |
| Gene | SNX19 |
| Featue | |
| Evidence | PubMed ID:18073581 |
| Drugs | |
| Diseases | Coronary Disease |
| Curation Level | Curated |
