From SNPedia
rs2295490 is a SNP in the tribbles homolog 3
TRIB3 gene, also known as Q84R. The (A) allele encodes the Gln (Q), while the (G) allele encodes the Arg (R).
A study involving four different case-control samples comprising a total of 5469 Caucasisans determined that rs2295490(G) was nominally associated with type-2 diabetes (odds ratio 1.17, CI: 1.00-1.36, p = 0.04). When stratified by age of diabetes onset, these carriers had an increased risk of early-onset T2D (OR 1.32, CI: 1.10-1.58, p = 0.002).[PMID 18984671]
[PMID 19139803] this gain of function mutation may affect insulin signaling and increase the risk of insulin resistance
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| PharmGKB | PA162363984 |
| Name | TRIB3: Q84R |
| Annotation | This variant in the TRIB3 gene is associated with early-onset T2D in Whites. This Q84R "gain of function" polymorphism, impairs insulin signaling. |
| Gene | TRIB3 |
| Featue | |
| Evidence | PubMed ID:18984671 |
| Drugs | |
| Diseases | Diabetes Mellitus, Type 2 |
| Curation Level | Curated |
