From SNPedia
In an expanded follow-up study of >6,000 controls and 6,000 patients, in which
rs2292239 was chosen to replace the nearby
rs11171739 originally determined to be associated with
type-1 diabetes, the heterozygote odds ratio for this SNP was recalculated to be 1.28 (CI 1.20 - 1.36). [
PMID 17554260]
| ? | (A;A) (A;C) (C;C) |
|---|
 |
| GWAS snp
|
| PMID
| [PMID 18978792]
|
| Trait
| Type 1 diabetes
|
| Title
| Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
|
| Risk Allele
| A
|
| P-val
| 3E-16
|
| Odds Ratio
| NR NR
|
| GWAS snp
|
| PMID
| [PMID 19430480]
|
| Trait
| Type 1 diabetes
|
| Title
| Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
|
| Risk Allele
|
|
| P-val
| 2E-25
|
| Odds Ratio
| NR NR
|
Related to DIABETES MELLITUS, INSULIN-DEPENDENT; IDDM
according to
omim 222100. See
also
Related to V-ERB-B2 AVIAN ERYTHROBLASTIC LEUKEMIA VIRAL ONCOGENE HOMOLOG 3; ERBB3
according to
omim 190151. See
also
| PharmGKB | PA162356632 |
| Name | |
| Annotation | GWAS Results: Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes (Initial Sample Size: 1,963 cases, 2,938 controls; Replication Sample Size: 4,000 cases, 5,000 controls, 2,997 trios; Risk Allele: rs2292239-A). |
| Gene | ERBB3 |
| Featue | |
| Evidence | PubMed ID:17554260; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Diabetes Mellitus, Diabetes Mellitus, Type 1 |
| Curation Level | Non-Curated |
[PMID 19951419] Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis
