Rs2270641

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is asnp
is mentioned by
dbSNPrs2270641
hapmaprs2270641
hgdprs2270641
ensemblrs2270641
gopubmedrs2270641
scholarrs2270641
googlers2270641
pharmgkbrs2270641
hgvbaseg2prs2270641
medrefsnprs2270641
23andMers2270641
SNP Nexus

GeneSLC18A1
Chromosome8
Orientationplus
Position20082745
GenotypeEffect
rs2270641(A;A)3.7x higher risk for schizophrenia
rs2270641(A;T)?
rs2270641(T;T)normal


Genotypes Magnitude Summary
Rs2270641(A;A) 3.7x higher risk for schizophrenia
Rs2270641(A;T) ?
Rs2270641(T;T) normal
rs2270641 is a SNP in the vesicular monoamine transporter SLC18A1 gene, encoding a Thr4Pro substitution. In dbSNP orientation, the (G) allele is associated with the Proline.

A study of 62 patients with schizophrenia concluded that the frequency of rs2270641(G;G) homozygotes was significantly higher. The reported odds ratio was 3.74 (CI: 1.7-8.2, p=0.0006) in this population of European descent.[PMID 18451639]

Note: another SNP, rs56575139, marks the same genomic location as rs2270641.

? (A;A) (A;T) (T;T)