Rs224136

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Orientationplus
is asnp
is mentioned by
dbSNPrs224136
PheGenIrs224136
nextbiors224136
hapmaprs224136
1000 genomesrs224136
hgdprs224136
ensemblrs224136
gopubmedrs224136
geneviewrs224136
scholarrs224136
googlers224136
pharmgkbrs224136
gwascentralrs224136
openSNPrs224136
23andMers224136
23andMe allrs224136
SNP Nexus

SNPshotrs224136
SNPdbers224136
MSV3drs224136
Chromosome10
Orientationplus
GMAF0.3577
Position64470675
ReferenceGRCh37 37.1/131
Max Magnitude
Make rs224136(C;C)
Make rs224136(C;T)
Make rs224136(T;T)
? (C;C) (C;T) (T;T) 28
Rs224136
PubMed [PMID 17435756OA-icon.png]
Affy Probeset SNP_A-1883807
Affy Orientation reverse
On GW 5.0 1
Alleles A/B A/G
Ancestral T
Population EU
Allele C
Case Freq. 0.87
Control Freq. 0.81
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All 1.67
Disease Crohn's disease (CD)


Carriers of the C allele of rs224136 reportedly have 1.67 times higher susceptibility to Crohn's disease. [PMID 17435756OA-icon.png]

Rs224136 is not a major genetic risk factor for susceptibility to Crohn's disease in the German population. [PMID 19262523]

GWAS
SNP rs224136
PubMedID [PMID 17435756OA-icon.png]
Condition Crohn's disease
Gene Intergenic
Risk Allele
pValue 1.00E-010
OR 1.67
95% CI


OMIM612255
DescINFLAMMATORY BOWEL DISEASE 15; IBD15
Variant
Relatedalso
OMIM266600
DescINFLAMMATORY BOWEL DISEASE 1; IBD1
Variant
Relatedalso



[PMID 17068223] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.


[PMID 20195480OA-icon.png] The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease.


[PMID 20222171OA-icon.png] T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.


GET Evidence
rs224136
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.390625
summary