Rs1992660

Orientation

minus

is a	snp
is	mentioned by
dbSNP	rs1992660
PheGenI	rs1992660
nextbio	rs1992660
hapmap	rs1992660
1000 genomes	rs1992660
hgdp	rs1992660
ensembl	rs1992660
gopubmed	rs1992660
geneview	rs1992660
scholar	rs1992660
google	rs1992660
pharmgkb	rs1992660
gwascentral	rs1992660
openSNP	rs1992660
23andMe	rs1992660
23andMe all	rs1992660
SNP Nexus
SNPshot	rs1992660
SNPdbe	rs1992660
MSV3d	rs1992660

Gene

PTGER4

Chromosome

5

Orientation

minus

GMAF

0.462

Position

40415067

Reference

GRCh37 37.1/131

Max Magnitude

Geno	Mag	Summary
(A;A)		increased risk for Crohn's disease
(A;G)		?
(G;G)		0.72x decreased risk for Crohn's disease

?	(A;A) (A;G) (G;G)	28

rs1992660 is a SNP upstream of the PTGER4 gene that was found in a genome-wide association study to be associated with Crohn's disease.

In several European populations, the most common allele, rs1992660(A), was associated with increased risk for Crohn's disease. Conversely, the odds ratio (pooled over several populations) for the minor allele, rs1992660(G), was 0.72 (CI: 0.60-0.86, p=0.0005).[PMID 17684544]

GWAS
SNP	rs1992660
PubMedID	[PMID 17684544]
Condition	Irritable bowel syndrome
Gene	PTGER4
Risk Allele
pValue	4.00E-007
OR	1.42
95% CI	1.24-1.67

OMIM	612262
Desc	INFLAMMATORY BOWEL DISEASE 18; IBD18
Variant
Related	also

GET Evidence
rs1992660
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.563492
summary