Rs1990760
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1990760 |
| hapmap | rs1990760 |
| hgdp | rs1990760 |
| ensembl | rs1990760 |
| gopubmed | rs1990760 |
| scholar | rs1990760 |
| rs1990760 | |
| pharmgkb | rs1990760 |
| hgvbaseg2p | rs1990760 |
| medrefsnp | rs1990760 |
| 23andMe | rs1990760 |
| SNP Nexus |
| Gene | IFIH1 |
| Chromosome | 2 |
| Orientation | plus |
| Position | 162832296 |
| Genotype | Effect |
|---|---|
| rs1990760(C;C)* | ? |
| rs1990760(C;T)* | ? |
| rs1990760(T;T)* | ? |
associated with type-1 diabetes, organ-specific autoimmune diseases, including Graves' disease. (odds ratio 1.47 (CI: 1.23–1.76, p = 1.9 x 10–5)
This polymorphism may also contribute to several other autoimmune disorders.
[PMID 18026693] A study of 261 Chinese patients with Graves' disease failed to find any association with rs1990760.
[PMID 19156166] A study of 591 French Caucasian multiple sclerosis trio families found no association between rs1990760 or rs2068330 and the disease, which did not confirm one previously reported study.
| ? | (C;T) (T;T) |
|---|---|
|
| |
| GWAS snp | |
|---|---|
| PMID | [PMID 17554260] |
| Trait | Type 1 diabetes |
| Title | Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes |
| Risk Allele | A |
| P-val | 1.9999999999999999E-11 |
| Odds Ratio | 1.18 [1.11-1.23] |
| GWAS snp | |
|---|---|
| PMID | [PMID 19430480] |
| Trait | Type 1 diabetes |
| Title | Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes |
| Risk Allele | |
| P-val | 7E-9 |
| Odds Ratio | NR NR |
[PMID 19450885] Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1
[PMID 19841890] The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations
[PMID 19956106] Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families
[PMID 19951419] Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis
