Rs1934951

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Orientationminus
is asnp
is mentioned by
dbSNPrs1934951
PheGenIrs1934951
nextbiors1934951
hapmaprs1934951
1000 genomesrs1934951
hgdprs1934951
ensemblrs1934951
gopubmedrs1934951
geneviewrs1934951
scholarrs1934951
googlers1934951
pharmgkbrs1934951
gwascentralrs1934951
openSNPrs1934951
23andMers1934951
23andMe allrs1934951
SNP Nexus

SNPshotrs1934951
SNPdbers1934951
MSV3drs1934951
GeneCYP2C8
Chromosome10
Orientationminus
GMAF0.2787
Position96798548
ReferenceGRCh37 37.1/131
Max Magnitude
Make rs1934951(A;A)
Make rs1934951(A;G)
Make rs1934951(G;G)
? (A;A) (A;G) (G;G) 28

[PMID 18594024] (T;T) associated with a higher risk of osteonecrosis of the jaw in am small study of multiple myeloma patients under bisphosphonate therapy

GWAS
SNP rs1934951
PubMedID [PMID 18594024]
Condition Osteonecrosis of the jaw
Gene CYP2C8
Risk Allele T
pValue 1.00E-006
OR 12.75
95% CI 3.7-43.5


OMIM254500
DescMYELOMA, MULTIPLE
Variant
Relatedalso
[PMID 21151627OA-icon.png] A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer


[PMID 21685474OA-icon.png] CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma


[PMID 22339777] New approach to analyze genetic and clinical data in bisphosphonate-induced osteonecrosis of the jaw


GET Evidence
rs1934951
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.320312
summary



[PMID 23171856] Association between CYP2C8 (rs1934951) Polymorphism and Bisphosphonate-Related Osteonecrosis of the Jaws in Patients on Bisphosphonate Therapy: A Meta-Analysis