Rs1934951

Orientation

minus

is a	snp
is	mentioned by
dbSNP	rs1934951
PheGenI	rs1934951
nextbio	rs1934951
hapmap	rs1934951
1000 genomes	rs1934951
hgdp	rs1934951
ensembl	rs1934951
gopubmed	rs1934951
geneview	rs1934951
scholar	rs1934951
google	rs1934951
pharmgkb	rs1934951
gwascentral	rs1934951
openSNP	rs1934951
23andMe	rs1934951
23andMe all	rs1934951
SNP Nexus
SNPshot	rs1934951
SNPdbe	rs1934951
MSV3d	rs1934951

Gene

CYP2C8

Chromosome

10

Orientation

minus

GMAF

0.2788

Position

96798548

Reference

GRCh37 37.1/131

Max Magnitude

Make rs1934951(A;A)

Make rs1934951(A;G)

Make rs1934951(G;G)

?	(A;A) (A;G) (G;G)	28

[PMID 18594024] (T;T) associated with a higher risk of osteonecrosis of the jaw in am small study of multiple myeloma patients under bisphosphonate therapy

GWAS
SNP	rs1934951
PubMedID	[PMID 18594024]
Condition	Osteonecrosis of the jaw
Gene	CYP2C8
Risk Allele	T
pValue	1.00E-006
OR	12.75
95% CI	3.7-43.5

OMIM	254500
Desc	MYELOMA, MULTIPLE
Variant
Related	also

[PMID 21151627] A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer

[PMID 21685474] CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma

[PMID 22339777] New approach to analyze genetic and clinical data in bisphosphonate-induced osteonecrosis of the jaw

GET Evidence
rs1934951
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.320312
summary

[PMID 23171856] Association between CYP2C8 (rs1934951) Polymorphism and Bisphosphonate-Related Osteonecrosis of the Jaws in Patients on Bisphosphonate Therapy: A Meta-Analysis