Rs1889018
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1889018 |
| hapmap | rs1889018 |
| hgdp | rs1889018 |
| ensembl | rs1889018 |
| gopubmed | rs1889018 |
| scholar | rs1889018 |
| rs1889018 | |
| pharmgkb | rs1889018 |
| hgvbaseg2p | rs1889018 |
| medrefsnp | rs1889018 |
| 23andMe | rs1889018 |
| SNP Nexus |
| Gene | SREBF1 |
| Chromosome | 17 |
| Orientation | minus |
| Position | 17675464 |
| Genotype | Effect |
|---|---|
| rs1889018(C;C) | normal |
| rs1889018(C;T) | 1.12x increased risk for T2D |
| rs1889018(T;T) | 1.12x increased risk for T2D |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs1889018(C;C) | normal | |
| Rs1889018(C;T) | 1.12x increased risk for T2D | |
| Rs1889018(T;T) | 00 | 1.12x increased risk for T2D |
A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.12 (CI: 1.01-1.24, p=0.04) for the minor (risk) allele, rs1889018(T). This allele was also associated with a surrogate measure of insulin sensitivity (p=0.03).[PMID 18192539]
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
