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Geno Mag Summary
(A;A) slightly higher breast cancer risk
(A;G) slightly higher breast cancer risk
(G;G) 0 normal
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs1799969
23andMe allrs1799969
SNP Nexus

Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs1799969, also known as G241R or +241G/A, is a SNP in the ICAM1 gene. The more common (G) allele encodes the glycine (G).

A study of 276 Iranian breast cancer patients concluded (p = 0.008) that rs1799969(A) allele carriers may have a higher risk of developing breast cancer.[PMID 18474291]

SNP rs1799969
PubMedID [PMID 18604267OA-icon.png]
Condition Soluble ICAM-1
Gene ICAM1
Risk Allele G
pValue 4.00E-047
OR 28.19
95% CI NR) umol/L decreas

[PMID 19332210OA-icon.png] Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: Data from the Women's Genome Health Study

[PMID 18420209OA-icon.png] ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA)

[PMID 20031590OA-icon.png] The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations

[PMID 20585554OA-icon.png] On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study

[PMID 21245421] Genetic Factors Underlying the Risk of Thalidomide-Related Neuropathy in Patients With Multiple Myeloma

GWAS snp
PMID [PMID 21533024OA-icon.png]
Title Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.
Risk Allele A
P-val 1E-120
Odds Ratio 24.9000 [NR] ng/mL decrease

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16385446OA-icon.png] A testing framework for identifying susceptibility genes in the presence of epistasis.

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 17903293OA-icon.png] Genome-wide association with select biomarker traits in the Framingham Heart Study.

[PMID 18045485OA-icon.png] The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.

[PMID 18505543OA-icon.png] Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.

[PMID 18513389OA-icon.png] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.

[PMID 18528404OA-icon.png] Variation in the ICAM1 gene is not associated with severe malaria phenotypes.

[PMID 18703101] ICAM1 R241 is not associated with celiac disease in the Spanish population.

[PMID 18778477OA-icon.png] Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19474294OA-icon.png] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 22388798OA-icon.png] Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.

GET Evidence
aa_change Gly241Arg
aa_change_short G241R
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0754787

[PMID 24289603] Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors