Rs1799969

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Orientationplus
is asnp
is mentioned by
dbSNPrs1799969
PheGenIrs1799969
nextbiors1799969
hapmaprs1799969
1000 genomesrs1799969
hgdprs1799969
ensemblrs1799969
gopubmedrs1799969
geneviewrs1799969
scholarrs1799969
googlers1799969
pharmgkbrs1799969
gwascentralrs1799969
openSNPrs1799969
23andMers1799969
23andMe allrs1799969
SNP Nexus

SNPshotrs1799969
SNPdbers1799969
MSV3drs1799969
GeneICAM1
Chromosome19
Orientationplus
GMAF0.07071
Position10394792
ReferenceGRCh37 37.1/131
Max Magnitude0
Geno Mag Summary
(A;A) slightly higher breast cancer risk
(A;G) slightly higher breast cancer risk
(G;G) 0 normal
? (A;A) (A;G) (G;G) 28
rs1799969, also known as G241R or +241G/A, is a SNP in the ICAM1 gene. The more common (G) allele encodes the glycine (G).

A study of 276 Iranian breast cancer patients concluded (p = 0.008) that rs1799969(A) allele carriers may have a higher risk of developing breast cancer.[PMID 18474291]

Neighborrs5498
Distance891
GWAS
SNP rs1799969
PubMedID [PMID 18604267OA-icon.png]
Condition Soluble ICAM-1
Gene ICAM1
Risk Allele G
pValue 4.00E-047
OR 28.19
95% CI NR) umol/L decreas


[PMID 19332210OA-icon.png] Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: Data from the Women's Genome Health Study


[PMID 18420209OA-icon.png] ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA)


[PMID 20031590OA-icon.png] The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations


[PMID 20585554OA-icon.png] On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study

[PMID 21245421] Genetic Factors Underlying the Risk of Thalidomide-Related Neuropathy in Patients With Multiple Myeloma

GWAS snp
PMID [PMID 21533024OA-icon.png]
Trait
Title Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.
Risk Allele A
P-val 1E-120
Odds Ratio 24.9000 [NR] ng/mL decrease


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 16385446OA-icon.png] A testing framework for identifying susceptibility genes in the presence of epistasis.


[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.


[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 17903293OA-icon.png] Genome-wide association with select biomarker traits in the Framingham Heart Study.


[PMID 18045485OA-icon.png] The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.


[PMID 18505543OA-icon.png] Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.


[PMID 18513389OA-icon.png] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.


[PMID 18528404OA-icon.png] Variation in the ICAM1 gene is not associated with severe malaria phenotypes.


[PMID 18703101] ICAM1 R241 is not associated with celiac disease in the Spanish population.


[PMID 18778477OA-icon.png] Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19474294OA-icon.png] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 22388798OA-icon.png] Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.


GET Evidence
ICAM1-G241R
aa_change Gly241Arg
aa_change_short G241R
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0754787
summary



[PMID 24289603] Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors