From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
normal breast cancer risk
|
| (A;G)
|
|
increased breast cancer risk
|
| (G;G)
|
2
|
increased breast cancer risk
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
This SNP, a variant in the
BRCA1 gene, is 1 of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for
breast cancer. [
PMID 17341484]
For details of all 25 SNPs in this group, along with the two methods used to calculate overall risk estimates for breast cancer, refer to the SNPedia breast cancer entry.
This particular SNP, rs1799950, was actually the only SNP of the 25 to have an increased odds ratio for breast cancer to be over 1.5 in carriers and to also be present at a minor allele frequency of over 5%. The odds ratio calculated was 1.72 (P = 0.0002). The risk (minor) allele is (G).
[PMID 22144497] Assessing the clinical role of genetic markers of early-onset prostate cancer among high-risk men enrolled in prostate cancer early detection
