Rs17824933

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Orientationplus
Geno Mag Summary
(C;C) 0 common on affy axiom data
Make rs17824933(C;G)
Make rs17824933(G;G)
ReferenceGRCh38 38.1/141
Chromosome11
Position60993140
GeneCD6
is asnp
is mentioned by
dbSNPrs17824933
PheGenIrs17824933
nextbiors17824933
hapmaprs17824933
1000 genomesrs17824933
hgdprs17824933
ensemblrs17824933
gopubmedrs17824933
geneviewrs17824933
scholarrs17824933
googlers17824933
pharmgkbrs17824933
gwascentralrs17824933
openSNPrs17824933
23andMers17824933
23andMe allrs17824933
SNP Nexus

SNPshotrs17824933
SNPdbers17824933
MSV3drs17824933
GMAF0.1111
Max Magnitude0
? (C;C) (C;G) (G;G) 28
rs17824933 is a SNP in the region of the CD6 gene.

A large study (~5,000 patients) found an increased risk for multiple sclerosis associated with rs17824933; the odds ratio for the minor allele was reported as 1.18 (CI: 1.07-1.30, p=3.79x10(-9)).10.1038/ng.401

GWAS snp
PMID [PMID 19525953OA-icon.png]
Trait Multiple sclerosis
Title Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Risk Allele G
P-val 4E-9
Odds Ratio 1.18 [1.07-1.30]


[PMID 19825846OA-icon.png] Genome-wide analysis of allelic expression imbalance in human primary cells by high throughput transcriptome resequencing

[PMID 20430450] Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain

OMIM126200
Desc
Variant
Relatedalso
[PMID 21552549OA-icon.png] The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study

[PMID 20405052OA-icon.png] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.


[PMID 21849685] The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.


GET Evidence
rs17824933
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.0819672
summary



[PMID 23638056OA-icon.png] Fine Mapping and Functional Analysis of the Multiple Sclerosis Risk Gene CD6