From SNPedia
Within the
FTO gene, many SNPs appear to be co-inherited. The SNP showing the strongest association with body weight (i.e. body mass index, BMI) is not
rs17817449, although this SNP is one of co-inherited SNPs in the
FTO gene region. For more information, refer to the
FTO gene or the most studied of
FTO SNPs,
rs9930506. [
PMID 17658951]
[PMID 18316358] A study of 900+ Quebec individuals reported that rs17817449 was associated with BMI (p=0.0014), weight (p=0.0059) and waist circumference (p=0.0021) under an additive model, and in addition, influenced fasting insulin (p=0.011) and HOMA-IR (p=0.038).
- Note: The three FTO SNPs, rs1421085, rs17817449, and rs9939609, are in strong linkage disequilibrium (pairwise r2>0.97), and there are two primary haplotypes, C-G-A (42.0 %) and T-T-T (55.5 %).
[PMID 18719664] This SNP is also associated with adult obesity in Mexicans.
[PMID 18551112] rs1421085(C) and rs17817449(G) significantly associated with increased BMI. Our results suggest that FTO may be one of the worldwide obesity-risk genes.
| ? | (G;G) (G;T) (T;T) |
|---|
 |
[PMID 19278366] A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies.
[PMID 19322589] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
Related to BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 14; BMIQ14
according to
omim 612460. See
also
| PharmGKB | PA161660931 |
| Name | |
| Annotation | The variant is significantly associated with several obesity-related phenotypes. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:18316358 |
| Drugs | |
| Diseases | Obesity |
| Curation Level | Curated |
