Rs17388568
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs17388568 |
| hapmap | rs17388568 |
| hgdp | rs17388568 |
| ensembl | rs17388568 |
| gopubmed | rs17388568 |
| scholar | rs17388568 |
| rs17388568 | |
| pharmgkb | rs17388568 |
| hgvbaseg2p | rs17388568 |
| medrefsnp | rs17388568 |
| 23andMe | rs17388568 |
| SNP Nexus |
| Gene | Tenr |
| Chromosome | 4 |
| Orientation | plus |
| Position | 123548811 |
| Genotype | Effect |
|---|---|
| rs17388568(A;A) | 1.6x risk |
| rs17388568(A;G) | 1.3x risk |
| rs17388568(G;G) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs17388568(A;A) | 1.6x risk | |
| Rs17388568(A;G) | 1.3x risk | |
| Rs17388568(G;G) | 00 | normal |
rs17388568 has been reported in a large study to be associated with type-1 diabetes.
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.26 (CI 1.11-1.42), and for homozygotes, 1.58 (CI 1.27-1.95). [PMID 17554300]
In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.11 (CI 1.05–1.18). [PMID 17554260]
| ? | (A;A) (A;G) (G;G) |
|---|---|
|
| |
| GWAS | |
|---|---|
| SNP | rs17388568 |
| PubMedID | [PMID 17554300] |
| Condition | Type 1 diabetes |
| Gene | NR |
| Risk Allele | A |
| pValue | 3.00E-006 |
| OR | 1.26 |
| 95% CI | 1.11-1.42 |
Related to DIABETES MELLITUS, INSULIN-DEPENDENT, 23; IDDM23
according to omim 612622. See also
Related to DIABETES MELLITUS, INSULIN-DEPENDENT; IDDM
according to omim 222100. See also
| PharmGKB | PA162356644 |
| Name | |
| Annotation | GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,963 cases, 2,938 controls; Replication Sample Size: (see Todd 2007); Risk Allele: rs17388568-A). This variant is associated with type 1 diabetes. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Diabetes Mellitus, Diabetes Mellitus, Type 1 |
| Curation Level | Non-Curated |
[PMID 20184734] The 4q27 locus and familial prostate cancer risk
