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rs17388568 has been reported in a large study to be associated with type-1 diabetes.
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.26 (CI 1.11-1.42), and for homozygotes, 1.58 (CI 1.27-1.95). [PMID 17554300]
In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.11 (CI 1.05â€“1.18). [PMID 17554260]
|Condition||Type 1 diabetes|
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|Odds Ratio||1.1200 [1.07-1.17]|
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|Odds Ratio||1.1000 [NR]|
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|qualified_impact||Insufficiently evaluated pathogenic|
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|Odds Ratio||.07 [0.047-0.099] unit increase|