rs17388568 has been reported in a large study to be associated with type-1 diabetes.
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.26 (CI 1.11-1.42), and for homozygotes, 1.58 (CI 1.27-1.95). [PMID 17554300]
In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.11 (CI 1.05â€“1.18). [PMID 17554260]
|Condition||Type 1 diabetes|
[PMID 20184734] The 4q27 locus and familial prostate cancer risk
[PMID 20553587] Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
|Title||Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47|
|Odds Ratio||1.1200 [1.07-1.17]|
|Title||Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.|
|Odds Ratio||1.1000 [NR]|
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[PMID 19201773] Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.
[PMID 19359276] Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.
[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
[PMID 20722033] The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
[PMID 21875375] Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients.
|qualified_impact||Insufficiently evaluated pathogenic|