Rs17367504

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Orientationplus
is asnp
is mentioned by
dbSNPrs17367504
PheGenIrs17367504
nextbiors17367504
hapmaprs17367504
1000 genomesrs17367504
hgdprs17367504
ensemblrs17367504
gopubmedrs17367504
geneviewrs17367504
scholarrs17367504
googlers17367504
pharmgkbrs17367504
gwascentralrs17367504
openSNPrs17367504
23andMers17367504
23andMe allrs17367504
SNP Nexus

SNPshotrs17367504
SNPdbers17367504
MSV3drs17367504
GeneMTHFR
Chromosome1
Orientationplus
GMAF0.1097
Position11862778
ReferenceGRCh37 37.1/131
Max Magnitude0
Geno Mag Summary
(A;A) 0
Make rs17367504(A;G)
Make rs17367504(G;G)
? (A;A) (A;G) (G;G) 28

Each G allele is associated with 0.89 x odds of high blood pressure, according to 23andMe. [PMID 19430483OA-icon.png]

23andMe blog blood pressure

GWAS snp
PMID [PMID 19430483OA-icon.png]
Trait Systolic blood pressure
Title Genome-wide association study identifies eight loci associated with blood pressure
Risk Allele G
P-val 2E-13
Odds Ratio 0.85 [0.63-1.07] mm Hg decrease
GWAS snp
PMID [PMID 21909110OA-icon.png]
Trait
Title Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Risk Allele G
P-val 2E-16
Odds Ratio 0.5340 [0.40-0.66] mmHg decrease


[PMID 19944404OA-icon.png] Genomic dissection of population substructure of Han Chinese and its implication in association studies.


[PMID 20031578OA-icon.png] Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.


[PMID 20852445] Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.


[PMID 22504314OA-icon.png] Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.


[PMID 22525200] Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms.


GET Evidence
rs17367504
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.0625
summary



High Blood Pressure (Hypertension)


[PMID 22959498] Recapitulation of four hypertension susceptibility genes (CSK, CYP17A1, MTHFR, and FGF5) in East Asians.