Rs17228212

Orientation

plus

is a	snp
is	mentioned by
dbSNP	rs17228212
PheGenI	rs17228212
nextbio	rs17228212
hapmap	rs17228212
1000 genomes	rs17228212
hgdp	rs17228212
ensembl	rs17228212
gopubmed	rs17228212
geneview	rs17228212
scholar	rs17228212
google	rs17228212
pharmgkb	rs17228212
gwascentral	rs17228212
openSNP	rs17228212
23andMe	rs17228212
23andMe all	rs17228212
SNP Nexus
SNPshot	rs17228212
SNPdbe	rs17228212
MSV3d	rs17228212

Gene

SMAD3

Chromosome

15

Orientation

plus

GMAF

0.1557

Position

67458639

Reference

GRCh37 37.1/131

Max Magnitude

2

Geno	Mag	Summary
(A;A)	0
(C;C)	2	>1.26x increased risk for heart disease
(C;T)		1.26x increased risk for heart disease
(T;T)	0	normal

?	(C;C) (C;T) (T;T)	28

rs17228212 is a SNP found to be associated with heart disease by the German MI (Myocardial infarction) Family Study group in two populations. The odds ratio per allele is 1.26 (CI: 1.11-1.44, p=0.0178).[PMID 17634449]

[PMID 18979498] rs599839, rs4970834 and rs17228212 associated with non-HDL cholesterol

[PMID 18780302] Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

[PMID 19198609] Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

[PMID 19750184] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.

[PMID 20017983] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.

[PMID 20098575] Genetics and cardiovascular disease: Design and development of a DNA biobank.

[PMID 21804106] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

GET Evidence
rs17228212
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.1875
summary