Rs17070145

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is asnp
is mentioned by
dbSNPrs17070145
nextbiors17070145
hapmaprs17070145
1000 genomesrs17070145
hgdprs17070145
ensemblrs17070145
gopubmedrs17070145
scholarrs17070145
googlers17070145
pharmgkbrs17070145
gwascentralrs17070145
openSNPrs17070145
23andMers17070145
23andMe allrs17070145
SNP Nexus

SNPshotrs17070145
SNPdbers17070145
MSV3drs17070145
GeneWWC1
Chromosome5
Orientationplus
Position167845791
ReferenceGRCh37 37.1/131
Max Magnitude2.1
Geno Mag Summary
(C;C) 2.1 reduced memory abilities
(C;T) 2 increased memory performance
(T;T) 2.1 greatly increased memory performance
? (C;C) (C;T) (T;T) 28
[PMID 17053149] In a Swiss cohort: "Carriers of KIBRA rs17070145 T allele had 24% better free recall performance 5 min after word presentation (P = 0.000004) and 19% better free recall performance 24 hours after word presentation (P = 0.0008) than did noncarriers."

In a US cohort: "T allele carriers had significantly better memory scores than non-carriers in the Buschke's Selective Reminding Test (SRT). Performance on another episodic memory task, the Rey Auditory Verbal Learning Test (AVLT), was also significantly different between allele groups." In another Swiss cohort, with a visual episodic memory task: "T allele carriers also performed significantly better than did noncarriers in this population." "Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval."

[PMID 17353070] Replication in a healthy elderly cohort.

OMIM610533
DescWW, C2, AND COILED-COIL DOMAIN-CONTAINING 1; WWC1
Variant
Relatedalso

[PMID 19606085] Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use


[PMID 20150879] Single nucleotide polymorphism of the KIBRA gene in recurrent depressive disorders


[PMID 20185150] Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls


[PMID 20509760] Association study of KIBRA gene with memory performance in a Japanese population

[PMID 21185624] Association of common KIBRA variants with episodic memory and AD risk

OMIM610533
Desc
Variant0001
Relatedalso


[PMID 21976506] KIBRA Polymorphism Is Related to Enhanced Memory and Elevated Hippocampal Processing


[PMID 22457502] Interaction of BDNF and COMT Polymorphisms on Paired-Associative Stimulation-Induced Cortical Plasticity

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