Rs17070145
| is a | snp |
| is | mentioned by |
| dbSNP | rs17070145 |
| nextbio | rs17070145 |
| hapmap | rs17070145 |
| 1000 genomes | rs17070145 |
| hgdp | rs17070145 |
| ensembl | rs17070145 |
| gopubmed | rs17070145 |
| scholar | rs17070145 |
| rs17070145 | |
| pharmgkb | rs17070145 |
| gwascentral | rs17070145 |
| openSNP | rs17070145 |
| 23andMe | rs17070145 |
| 23andMe all | rs17070145 |
| SNP Nexus | |
| SNPshot | rs17070145 |
| SNPdbe | rs17070145 |
| MSV3d | rs17070145 |
| Gene | WWC1 |
| Chromosome | 5 |
| Orientation | plus |
| Position | 167845791 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 2.1 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.1 | reduced memory abilities |
| (C;T) | 2 | increased memory performance |
| (T;T) | 2.1 | greatly increased memory performance |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
In a US cohort: "T allele carriers had significantly better memory scores than non-carriers in the Buschke's Selective Reminding Test (SRT). Performance on another episodic memory task, the Rey Auditory Verbal Learning Test (AVLT), was also significantly different between allele groups." In another Swiss cohort, with a visual episodic memory task: "T allele carriers also performed significantly better than did noncarriers in this population." "Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval."
[PMID 17353070] Replication in a healthy elderly cohort.
[PMID 19606085] Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use
[PMID 20150879] Single nucleotide polymorphism of the KIBRA gene in recurrent depressive disorders
[PMID 20185150] Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
[PMID 20509760] Association study of KIBRA gene with memory performance in a Japanese population
[PMID 21185624] Association of common KIBRA variants with episodic memory and AD risk
[PMID 21976506] KIBRA Polymorphism Is Related to Enhanced Memory and Elevated Hippocampal Processing
[PMID 22457502] Interaction of BDNF and COMT Polymorphisms on Paired-Associative Stimulation-Induced Cortical Plasticity