Rs17036314
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs17036314 |
| hapmap | rs17036314 |
| hgdp | rs17036314 |
| ensembl | rs17036314 |
| gopubmed | rs17036314 |
| scholar | rs17036314 |
| rs17036314 | |
| pharmgkb | rs17036314 |
| hgvbaseg2p | rs17036314 |
| medrefsnp | rs17036314 |
| 23andMe | rs17036314 |
| SNP Nexus |
| Gene | PPARG |
| Chromosome | 3 |
| Orientation | plus |
| Position | 12351744 |
| Genotype | Effect |
|---|---|
| rs17036314(C;C) | risk of progressing from IGT to T2D; reduced by exercise |
| rs17036314(C;G) | risk of progressing from IGT to T2D; reduced by exercise |
| rs17036314(G;G) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs17036314(C;C) | risk of progressing from IGT to T2D; reduced by exercise | |
| Rs17036314(C;G) | risk of progressing from IGT to T2D; reduced by exercise | |
| Rs17036314(G;G) | normal |
rs17036314 is a SNP in the peroxisome proliferator-activated receptor gamma PPARG gene.
In a 4 year study of 479 overweight individuals with impaired glucose tolerance (IGT) who participated in the Finnish Diabetes Prevention Study (DPS), carrying a rs17036314(C) allele predicted conversion to type-2 diabetes (T2D) after adjustment for baseline fasting glucose (p=0.030). Increased physical activity reduced this risk.[PMID 18091023]
| ? | (C;C) (C;G) (G;G) |
|---|---|
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| |
