From SNPedia
rs16901979 is a SNP on chromosome 8q24, associated with increased risk for prostate cancer in several studies. In some studies, the regions have been divided, and this SNP falls in region 2.
In a study of over 3,600 Caucasians with prostate cancer, rs16901979 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the rs16901979(A;A) and (A;C) risk genotypes yield an odds ratio for developing prostate cancer of 1.53 (CI: 1.22-1.92, p=1.8x10e-4) and may account for 3.6% of population attributable risk.10.1056/NEJMoa075819
cancer related according to this blog
Two genetic markers in the 8q24 region of chromosome 8 rs7008482 and rs16901979 have been linked to an increased risk of prostate cancer in African Americans. abstract
In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 2) of advanced prostate cancer.[PMID 18231127]]
A meta-analysis of 10+ studies comprising over 15,000 prostate cancer patients concluded that the odds ratio for rs16901979(A) allele carriers is 1.74 (CI: 1.72-1.77).[PMID 18231127]
| ? | (A;A) (A;C) (C;C) |
|---|
 |
| GWAS
|
| SNP
| rs16901979
|
| PubMedID
| [PMID 17401366]
|
| Condition
| Prostate cancer
|
| Gene
| Intergenic
|
| Risk Allele
| A
|
| pValue
| 1.00E-012
|
| OR
| 1.79
|
| 95% CI
| 1.53-2.11) (EA
|
[PMID 19549807] Prostate Cancer Risk Associated Loci in African Americans
[PMID 19562729] Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry
Related to PROSTATE CANCER, HEREDITARY, 10; HPC10
according to
omim 611100. See
also
| GWAS snp
|
| PMID
| [PMID 19767754]
|
| Trait
| Prostate cancer
|
| Title
| Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
|
| Risk Allele
| A
|
| P-val
| 3E-14
|
| Odds Ratio
| 1.80 [1.55-2.09]
|
[PMID 19908238] Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men
| PharmGKB | PA162356603 |
| Name | |
| Annotation | GWAS Results: Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 (Initial Sample Size: 1,435 cases, 3,064 controls; Replication Sample Size: 1,210 EA cases, 2,445 EA controls; 373 AA cases, 372 AA controls; Risk Allele: rs16901979-A). |
| Gene | SRRM1L |
| Featue | |
| Evidence | PubMed ID:17401366; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Prostatic Neoplasms |
| Curation Level | Non-Curated |
