Rs16260
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs16260 |
| hapmap | rs16260 |
| hgdp | rs16260 |
| ensembl | rs16260 |
| gopubmed | rs16260 |
| scholar | rs16260 |
| rs16260 | |
| pharmgkb | rs16260 |
| hgvbaseg2p | rs16260 |
| medrefsnp | rs16260 |
| 23andMe | rs16260 |
| SNP Nexus |
| Gene | CDH1 |
| Chromosome | 16 |
| Orientation | plus |
| Position | 67328534 |
| Genotype | Effect |
|---|---|
| rs16260(A;A) | 2.6x increased risk of prostate cancer |
| rs16260(A;C) | 1.5-1.7x increased risk of prostate cancer |
| rs16260(C;C) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs16260(A;A) | 2.6x increased risk of prostate cancer | |
| Rs16260(A;C) | 1.5-1.7x increased risk of prostate cancer | |
| Rs16260(C;C) | 00 | normal |
[PMID 14961571, PMID 16189707] rs16260 (A) SNP located in the promoter region of the E-cadherin CDH1 gene is associated with increased risk of hereditary prostate cancer.
The effect appears to be additive, in that compared to the rs16260(C;C) homozygotes, the rs16260(A;C) heterozygotes are at about a 1.5 - 1.7 fold increased risk, and the rs16260(A;A) homozygotes are at about a 2.6 fold increased risk.
- see also OMIM 192090.0018
| ? | (A;A) (A;C) (C;C) |
|---|---|
|
| |
[PMID 19569232] The CDH1-160C>A polymorphism is a risk factor for colorectal cancer
