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Rs1558902

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Orientationplus
is asnp
is mentioned by
dbSNPrs1558902
PheGenIrs1558902
nextbiors1558902
hapmaprs1558902
1000 genomesrs1558902
hgdprs1558902
ensemblrs1558902
gopubmedrs1558902
geneviewrs1558902
scholarrs1558902
googlers1558902
pharmgkbrs1558902
gwascentralrs1558902
openSNPrs1558902
23andMers1558902
23andMe allrs1558902
SNP Nexus

SNPshotrs1558902
SNPdbers1558902
MSV3drs1558902
GeneFTO
Chromosome16
Orientationplus
GMAF0.2479
Position53769662
ReferenceGRCh38 38.1/141
Max Magnitude
Make rs1558902(A;A)
Make rs1558902(A;T)
Make rs1558902(T;T)
? (A;A) (A;T) (T;T) 28
GWAS snp
PMID [PMID 19557197OA-icon.png]
Trait Waist circumference
Title NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium
Risk Allele
P-val 5E-19
Odds Ratio NR NR


[PMID 20075932] Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese

GWAS snp
PMID [PMID 20421936OA-icon.png]
Trait Obesity (extreme)
Title Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups
Risk Allele A
P-val 7E-13
Odds Ratio 1.37 [1.26-1.50]
GWAS snp
PMID [PMID 20935630OA-icon.png]
Trait
Title Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Risk Allele A
P-val 5E-120
Odds Ratio 0.39 [0.35-0.43] kg/m2 increase


[PMID 21443588] Association between the FTO gene and overweight in Japanese children and adolescents

GWAS snp
PMID [PMID 21544081]
Trait
Title Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.
Risk Allele T
P-val 1E-7
Odds Ratio 0.0900 [0.06-0.12] unit decrease


[PMID 21796137] Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population


[PMID 22235250OA-icon.png] Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height


[PMID 22589738OA-icon.png] Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

[PMID 18379722OA-icon.png] Variations in the FTO gene are associated with severe obesity in the Japanese.


[PMID 20703240] Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.


[PMID 22041983] Recapitulation of genome-wide association studies on body mass index in the Korean population.


[PMID 22222230] FTO gene polymorphisms and platelet counts in a general Japanese population.


[PMID 22504289] FTO, Abdominal Adiposity, Fasting Hyperglycemia Associated with Elevated HbA1c in Japanese Middle-Aged Women.


GET Evidence
rs1558902
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.285714
summary



[PMID 23254338] FTO First Intron rs1558902 Variant and Platelets Count in White Middle-aged Women: Prague Pre and Post Menopausal Females (3PMFs) Study


[PMID 24084939OA-icon.png] A common biological basis of obesity and nicotine addiction


[PMID 24106974] Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility

GWAS snp
PMID [PMID 23563607OA-icon.png]
Trait Obesity
Title Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Risk Allele A
P-val 2E-81
Odds Ratio 1.14 [NR]


[PMID 22891219OA-icon.png] FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial.


[PMID 23471855OA-icon.png] The genetics of childhood obesity and interaction with dietary macronutrients.


[PMID 24911064] Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents


[PMID 24983943] Effects of BMI, Fat Mass, and Lean Mass on Asthma in Childhood: A Mendelian Randomization Study