Rs1495377

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is asnp
is mentioned by
dbSNPrs1495377
hapmaprs1495377
hgdprs1495377
ensemblrs1495377
gopubmedrs1495377
scholarrs1495377
googlers1495377
pharmgkbrs1495377
hgvbaseg2prs1495377
medrefsnprs1495377
23andMers1495377
SNP Nexus

Chromosome12
Orientationminus
Position69863367
GenotypeEffect
rs1495377(G;G)1.5x risk
rs1495377(C;G)1.3x risk
rs1495377(C;C)normal


Genotypes Magnitude Summary
Rs1495377(C;C) normal
Rs1495377(C;G) 1.3x risk
Rs1495377(G;G) 1.5x risk

rs1495377 has been reported in a large study to be associated with type-2 diabetes.

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.28 (CI 1.11-1.49), and for homozygotes, 1.51 (CI 1.28-1.78). [PMID 17554300]

Note: orientation of this SNP is presumed correct but should be confirmed

? (C;C) (C;G) (G;G)
GWAS
SNP rs1495377
PubMedID [PMID 17554300]
Condition Type 2 diabetes
Gene NR
Risk Allele G
pValue 7.00E-006
OR 1.28
95% CI 1.11-1.49


PharmGKBPA162356643
Name
AnnotationGWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: (see Zeggini 2007); Risk Allele: rs1495377-G). This variant is associated with type 2 diabetes.
Gene-
Featue
EvidencePubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
Drugs
DiseasesDiabetes Mellitus, Diabetes Mellitus, Type 2
Curation LevelNon-Curated