From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
2.7
|
probably light-skinned, European ancestry
|
| (A;G)
|
2.5
|
mixed African/European ancestry possible
|
| (G;G)
|
2.6
|
probably darker-skinned, Asian or African ancestry
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
This SNP influences
skin pigmentation. The allele p.A111T,
rs1426654(A), indicates light-skinned european ancestry. [
PMID 16847698,
PMID 16357253]
It appears as if this SNP is a relatively new one in human evolution; one estimate [PMID 17182896] is that the rs1426654(A) allele, in other words, light skin pigmentation, spread through the European population around 6,000 - 12,000 years ago. Prior to that, "European ancestors" were most likely relatively brown-skinned.
This SNP is one of three from the SLC24A5 gene that can be analyzed to categorize the ancestry of a person as either European, African, or Asian, based on a 2009 study.[PMID 19440451]
The 3 SNPs are:
| OMIM | 113750 |
| Desc | SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 4; SHEP4 |
| Variant | |
| Related | also |
| OMIM | 609802 |
| Desc | SOLUTE CARRIER FAMILY 24 (SODIUM/POTASSIUM/CALCIUM EXCHANGER), MEMBER |
| Variant | |
| Related | also |
