From SNPedia
The (G) allele of
rs12722489, located in the first intron of the
IL2RA gene, is associated with a slight increase (25%) in risk of developing
multiple sclerosis.
10.1056/NEJMoa073493[PMID tbd; NEJM 357, 29 July 2007, DA Hafler et al.]
Note that the (G) allele is the most common at this position in all known populations.
blog post giving perspective on the significance of this snp
plos rs12722489 and rs2104286 influence multiple sclerosis and type-1 diabetes
| ? | (A;A) (A;G) (G;G) |
|---|
 |
Related to MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO, 2; MS2
according to
omim 612594. See
also
| PharmGKB | PA162356160 |
| Name | |
| Annotation | In a replicated GWAS of U.K. and U.S. case/parent trios, this variant was shown to be associated with multiple sclerosis risk. |
| Gene | IL2RA |
| Featue | |
| Evidence | PubMed ID:17660530 |
| Drugs | |
| Diseases | Multiple Sclerosis |
| Curation Level | Curated |
