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From SNPedia

Geno Mag Summary
(G;G) 0 common in complete genomics
Make rs1256049(A;A)
Make rs1256049(A;G)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs1256049
23andMe allrs1256049
SNP Nexus

GWAS Ctlgrs1256049
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs1256049 is a SNP in the estrogen receptor 2 gene ESR2.

[PMID 18939943] rs1256049(A) allele carriers have higher mean carotid artery intima-media thickness (CIMT) as well as maximal CIMT, but this result may be limited to the population studied, in this case individuals from the Cardiovascular Risk in Young Finns study.

[PMID 19298602] Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians.

[PMID 19111408OA-icon.png] Association of estrogen receptor 2 gene polymorphisms with obesity in women (obesity and estrogen receptor 2 gene)

[PMID 19032032OA-icon.png] Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women

[PMID 19715484] No Association between Estrogen Receptor Beta (ESR2) Polymorphisms and Uterine Leiomyoma

[PMID 20390341] A systematic review of the relationship between polymorphic sites in the estrogen receptor-beta (ESR2) gene and breast cancer risk

[PMID 20172949OA-icon.png] Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China

[PMID 21523342] Association of Rsa polymorphism of the estrogen receptor-? gene with rheumatoid arthritis

[PMID 22511967OA-icon.png] Potential Role of Aromatase over Estrogen Receptor Gene Polymorphisms in Migraine Susceptibility: A Case Control Study from North India

[PMID 22678799] [Association between estrogen receptor beta gene polymorphisms in Chinese Uygur patients and intrahepatic cholestasis of pregnancy]

[PMID 22759347OA-icon.png] Association of estrogen receptor beta variants and serum levels of estradiol with risk of colorectal cancer: a case control study

[PMID 16083630] [Association between single-nucleotide polymorphisms in estrogen receptor beta gene and risk of prostate cancer].

[PMID 16118344OA-icon.png] Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women.

[PMID 17540666] Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization.

[PMID 17916182] CA repeat and RsaI polymorphisms in ERbeta gene are not associated with infertility in Indian men.

[PMID 17935138OA-icon.png] Haplotypes of the estrogen receptor beta gene and breast cancer risk.

[PMID 18053221OA-icon.png] Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study.

[PMID 18304720] Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.

[PMID 18487282] Association between ESR2 genetic variants and risk of myocardial infarction.

[PMID 18579753OA-icon.png] Vascular actions of estrogens: functional implications.

[PMID 18592033OA-icon.png] Sex steroid-related candidate genes in psychiatric disorders.

[PMID 18627768] Pharmacogenetics of hormone replacement therapy for climacteric symptoms.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 18980759] Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect.

[PMID 18992263OA-icon.png] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.

[PMID 19337586OA-icon.png] Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?

[PMID 19438492] Estrogen receptor polymorphisms and the risk of endometrial cancer.

[PMID 19555469OA-icon.png] A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.

[PMID 19630952OA-icon.png] Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.

[PMID 19927160] Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women.

[PMID 20346360OA-icon.png] Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.

[PMID 20655613OA-icon.png] Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women.

[PMID 21429951] Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility.

[PMID 21570196] Estrogen receptor gene variants are associated with anxiety disorders in older women.

[PMID 21762042] Oestrogen receptor polymorphisms in female patients with rheumatoid arthritis.

[PMID 21804148OA-icon.png] Oestrogen receptor polymorphisms and late-life depression.

[PMID 22228197] Estrogen receptors alpha (rs2234693 and rs9340799), and beta (rs4986938 and rs1256049) genes polymorphism in prostate cancer: Evidence for association with risk and histopathological tumor characteristics in Iranian men.

[PMID 22324545] Are polymorphisms in oestrogen receptors genes associated with lipid levels in response to hormone therapy?

[PMID 22463697] Association of polymorphisms in the estrogen receptor beta (ESR2) with unexplained recurrent spontaneous abortion (URSA) in Chinese population.

[PMID 23352710] The single nucleotide polymorphism (SNP) of the estrogen receptor-β gene, rs1256049, is associated with knee osteoarthritis in Korean population

[PMID 23506158] Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men

[PMID 23686919] Impact of polymorphisms in the oestrogen receptors alpha and beta (ESR1, ESR2) genes on risk of vasculogenic erectile dysfunction

[PMID 23274843] Given breast cancer, is fat better than thin? Impact of the estrogen receptor beta gene polymorphisms

[PMID 24859835] The influence of ESR1 rs9340799 and ESR2 rs1256049 polymorphisms on prostate cancer risk

[PMID 25128001OA-icon.png] Polymorphisms in estrogen receptors predict the risk of male infertility: a meta-analysis

[PMID 25973102OA-icon.png] Single nucleotide polymorphisms of ERβ and coronary atherosclerotic disease in Chinese Han women