Rs11986220

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Orientationplus
is asnp
is mentioned by
dbSNPrs11986220
PheGenIrs11986220
nextbiors11986220
hapmaprs11986220
1000 genomesrs11986220
hgdprs11986220
ensemblrs11986220
gopubmedrs11986220
geneviewrs11986220
scholarrs11986220
googlers11986220
pharmgkbrs11986220
gwascentralrs11986220
openSNPrs11986220
23andMers11986220
23andMe allrs11986220
SNP Nexus

SNPshotrs11986220
SNPdbers11986220
MSV3drs11986220
Chromosome8
Orientationplus
GMAF0.1038
Position128531689
ReferenceGRCh37 37.1/131
Max Magnitude
Make rs11986220(A;A)
Make rs11986220(A;T)
Make rs11986220(T;T)
? (A;A) (A;T) (T;T) 28

10.1371 PLOS reports that rs11986220 in 8q24 resides within a FoxA1 binding site, with the prostate cancer risk allele facilitating both stronger FoxA1 binding and stronger androgen responsiveness, due to the A allele forming a more perfect FoxA1/HNF3? binding site than the T allele. Nearby rs6983267 is a succeptibility marker for prostate cancer and colon cancer.

[PMID 19680443OA-icon.png] Functional enhancers at the gene-poor 8q24 cancer-linked locus


[PMID 22099997] Risk loci on chromosome 8q24 are associated with prostate cancer in northern Chinese men.