10.1371 PLOS reports that rs11986220 in 8q24 resides within a FoxA1 binding site, with the prostate cancer risk allele facilitating both stronger FoxA1 binding and stronger androgen responsiveness, due to the A allele forming a more perfect FoxA1/HNF3? binding site than the T allele. Nearby rs6983267 is a succeptibility marker for prostate cancer and colon cancer.
[PMID 19680443] Functional enhancers at the gene-poor 8q24 cancer-linked locus
[PMID 22099997] Risk loci on chromosome 8q24 are associated with prostate cancer in northern Chinese men.