Rs11574637

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Orientationplus
is asnp
is mentioned by
dbSNPrs11574637
PheGenIrs11574637
nextbiors11574637
hapmaprs11574637
1000 genomesrs11574637
hgdprs11574637
ensemblrs11574637
gopubmedrs11574637
geneviewrs11574637
scholarrs11574637
googlers11574637
pharmgkbrs11574637
gwascentralrs11574637
openSNPrs11574637
23andMers11574637
23andMe allrs11574637
SNP Nexus

SNPshotrs11574637
SNPdbers11574637
MSV3drs11574637
GeneITGAX
Chromosome16
Orientationplus
GMAF0.1579
Position31368874
ReferenceGRCh37 37.1/131
Max Magnitude
Make rs11574637(C;C)
Make rs11574637(C;T)
Make rs11574637(T;T)
? (C;C) (C;T) (T;T) 28

Associated with systemic lupus erythematosus (SLE) [PMID 18204098]

GWAS
SNP rs11574637
PubMedID [PMID 18204098]
Condition Systemic lupus erythematosus
Gene ITGAM, ITGAX
Risk Allele C
pValue 3.00E-011
OR 1.33
95% CI 1.22-1.46


OMIM609939
DescSYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6
Variant
Relatedalso
OMIM151510
DescINTEGRIN, ALPHA-X; ITGAX
Variant
Relatedalso
[PMID 21362770OA-icon.png] Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts


[PMID 19129174OA-icon.png] Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).


[PMID 19286673OA-icon.png] ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.


[PMID 19997561OA-icon.png] Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).


[PMID 20629846] Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis.


GET Evidence
rs11574637
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.203125
summary