Rs11574637

Orientation

plus

is a	snp
is	mentioned by
dbSNP	rs11574637
PheGenI	rs11574637
nextbio	rs11574637
hapmap	rs11574637
1000 genomes	rs11574637
hgdp	rs11574637
ensembl	rs11574637
gopubmed	rs11574637
geneview	rs11574637
scholar	rs11574637
google	rs11574637
pharmgkb	rs11574637
gwascentral	rs11574637
openSNP	rs11574637
23andMe	rs11574637
23andMe all	rs11574637
SNP Nexus
SNPshot	rs11574637
SNPdbe	rs11574637
MSV3d	rs11574637

Gene

ITGAX

Chromosome

16

Orientation

plus

GMAF

0.1584

Position

31368874

Reference

GRCh37 37.1/131

Max Magnitude

Make rs11574637(C;C)

Make rs11574637(C;T)

Make rs11574637(T;T)

?	(C;C) (C;T) (T;T)	28

Associated with systemic lupus erythematosus (SLE) [PMID 18204098]

GWAS
SNP	rs11574637
PubMedID	[PMID 18204098]
Condition	Systemic lupus erythematosus
Gene	ITGAM, ITGAX
Risk Allele	C
pValue	3.00E-011
OR	1.33
95% CI	1.22-1.46

OMIM	609939
Desc	SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6
Variant
Related	also

OMIM	151510
Desc	INTEGRIN, ALPHA-X; ITGAX
Variant
Related	also

[PMID 21362770] Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts

[PMID 19129174] Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).

[PMID 19286673] ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.

[PMID 19997561] Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).

[PMID 20629846] Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis.

GET Evidence
rs11574637
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.203125
summary