Rs1143679
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1143679 |
| hapmap | rs1143679 |
| hgdp | rs1143679 |
| ensembl | rs1143679 |
| gopubmed | rs1143679 |
| scholar | rs1143679 |
| rs1143679 | |
| pharmgkb | rs1143679 |
| hgvbaseg2p | rs1143679 |
| medrefsnp | rs1143679 |
| 23andMe | rs1143679 |
| SNP Nexus |
| Gene | ITGAM |
| Chromosome | 16 |
| Orientation | plus |
| Position | 31184311 |
| Genotype | Effect |
|---|---|
| rs1143679(A;A) | >1.78x increased risk for SLE |
| rs1143679(A;G) | 1.78x increased risk for SLE |
| rs1143679(G;G) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs1143679(A;A) | >1.78x increased risk for SLE | |
| Rs1143679(A;G) | 1.78x increased risk for SLE | |
| Rs1143679(G;G) | 00 | normal |
[PMID 19129174] reconfirmed
Related to SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6
according to omim 609939. See also
Related to SYSTEMIC LUPUS ERYTHEMATOSUS; SLE
according to omim 152700. See also
Related to INTEGRIN, ALPHA-M; ITGAM
according to omim 120980. See also
[PMID 19714582] Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors
[PMID 19939855] ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash, and immunologic manifestations in lupus patients with European ancestry
| PharmGKB | PA161925611 |
| Name | ITGAM: R77H |
| Annotation | This nonsynonymous SNP is an associated with risk of systemic lupus erythematosus in a study with 3,818 individuals of European descent. |
| Gene | ITGAM |
| Featue | |
| Evidence | PubMed ID:18204448 |
| Drugs | |
| Diseases | Lupus Erythematosus, Systemic |
| Curation Level | Curated |
