From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
normal
|
| (C;T)
|
2
|
1.5x increased risk of wet ARMD
|
| (T;T)
|
2.2
|
3.9x increased risk of wet ARMD
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
, also known as Met72Thr, is a SNP in the
PEDF gene.
Analysis of 86 Taiwanese Chinese patients with wet age related macular degeneration (ARMD) found the (T) allele to be more frequent in patients than in controls (50% vs 31%; p =.0005). The rs1136287(T;T) genotype was also more prevalent in patients than in controls (odds ratio 3.9, p = .0015).[PMID 18226801]
[PMID 20132989] Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population
[PMID 20504225] Pigment Epithelium-Derived Factor Expression in Colorectal Cancer Patients
[PMID 20678803] Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration
[PMID 21174599] Pigment Epithelium-Derived Factor Gene Polymorphisms in Exudative Age-Related Degeneration in a Chinese Cohort
[PMID 22029535] Lack of Association with PEDF Met72Thr Variant in Neovascular Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Han Chinese Population
