Rs1136287
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1136287 |
| hapmap | rs1136287 |
| hgdp | rs1136287 |
| ensembl | rs1136287 |
| gopubmed | rs1136287 |
| scholar | rs1136287 |
| rs1136287 | |
| pharmgkb | rs1136287 |
| hgvbaseg2p | rs1136287 |
| medrefsnp | rs1136287 |
| 23andMe | rs1136287 |
| SNP Nexus |
| Gene | SERPINF1 |
| Chromosome | 17 |
| Orientation | plus |
| Position | 1620025 |
| Genotype | Effect |
|---|---|
| rs1136287(C;C) | normal |
| rs1136287(C;T) | 1.5x increased risk of wet ARMD |
| rs1136287(T;T) | 3.9x increased risk of wet ARMD |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs1136287(C;C) | 00 | normal |
| Rs1136287(C;T) | 1.5x increased risk of wet ARMD | |
| Rs1136287(T;T) | 2.22.2 | 3.9x increased risk of wet ARMD |
Analysis of 86 Taiwanese Chinese patients with wet age related macular degeneration (ARMD) found the (T) allele to be more frequent in patients than in controls (50% vs 31%; p =.0005). The rs1136287(T;T) genotype was also more prevalent in patients than in controls (odds ratio 3.9, p = .0015).[PMID 18226801]
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
[PMID 20132989] Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population
