Rs1131454

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Orientationplus
Make rs1131454(A;A)
Make rs1131454(A;G)
Make rs1131454(G;G)
ReferenceGRCh38 38.1/141
Chromosome12
Position112911065
GeneOAS1
is asnp
is mentioned by
dbSNPrs1131454
Exacrs1131454
PheGenIrs1131454
nextbiors1131454
hapmaprs1131454
1000 genomesrs1131454
hgdprs1131454
ensemblrs1131454
gopubmedrs1131454
geneviewrs1131454
scholarrs1131454
googlers1131454
pharmgkbrs1131454
gwascentralrs1131454
openSNPrs1131454
23andMers1131454
23andMe allrs1131454
SNP Nexus

SNPshotrs1131454
SNPdbers1131454
MSV3drs1131454
Merged fromRs3741981
GMAF0.4867
? (A;A) (A;G) (G;G) 28
OMIM164350
Desc
Variant0002
Relatedalso
[PMID 21638280OA-icon.png] 2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer


ClinVar
Risk rs1131454(A,C;A,C)
Alt rs1131454(A,C;A,C)
Reference rs1131454(G;G)
Significance Other
Disease Diabetes mellitus
Variation info
Gene OAS1
CLNDBN Diabetes mellitus, type 1, susceptibility to
Reversed 0
HGVS NC_000012.11:g.113348870G>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000015022.1,



[PMID 15732009OA-icon.png] Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.


[PMID 19247438OA-icon.png] Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.


[PMID 19434718OA-icon.png] Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.


[PMID 19956101OA-icon.png] Overview of the Rapid Response data.


[PMID 19956105OA-icon.png] Reassessment of the type I diabetes association of the OAS1 locus.


[PMID 20079393OA-icon.png] 2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine.


GET Evidence
OAS1-G162S
aa_change Gly162Ser
aa_change_short G162S
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.451571
summary



[PMID 22710942] Evaluate the relationship between polymorphisms of OAS1 gene and susceptibility to chronic hepatitis C with high resolution melting analysis.


[PMID 23337612] Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection.


[PMID 25205466OA-icon.png] Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism