Rs1131454

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Orientationplus
is asnp
is mentioned by
dbSNPrs1131454
PheGenIrs1131454
nextbiors1131454
hapmaprs1131454
1000 genomesrs1131454
hgdprs1131454
ensemblrs1131454
gopubmedrs1131454
geneviewrs1131454
scholarrs1131454
googlers1131454
pharmgkbrs1131454
gwascentralrs1131454
openSNPrs1131454
23andMers1131454
23andMe allrs1131454
SNP Nexus

SNPshotrs1131454
SNPdbers1131454
MSV3drs1131454
GeneOAS1
Merged fromRs3741981
Chromosome12
Orientationplus
Position113348870
ReferenceGRCh37 37.1/131
Max Magnitude
Make rs1131454(A;A)
Make rs1131454(A;G)
Make rs1131454(G;G)
? (A;A) (A;G) (G;G) 28
OMIM164350
Desc
Variant0002
Relatedalso


[PMID 21638280] 2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer


ClinVar
Risk rs1131454(A,C;A,C)
Normal rs1131454(G;G)
Significance 255
Disease
ClinVar info
Gene OAS1
CLNDBN
Reversed 0
CLNHGVS NC_000012.11:g.113348870G>A
CLNSRC



[PMID 15732009] Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.


[PMID 19247438] Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.


[PMID 19434718] Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.


[PMID 19956101] Overview of the Rapid Response data.


[PMID 19956105] Reassessment of the type I diabetes association of the OAS1 locus.


[PMID 20079393] 2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine.


GET Evidence
OAS1-G162S
aa_change Gly162Ser
aa_change_short G162S
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.451571
summary
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