Rs1131341
| Orientation | minus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1131341 |
| PheGenI | rs1131341 |
| nextbio | rs1131341 |
| hapmap | rs1131341 |
| 1000 genomes | rs1131341 |
| hgdp | rs1131341 |
| ensembl | rs1131341 |
| gopubmed | rs1131341 |
| geneview | rs1131341 |
| scholar | rs1131341 |
| rs1131341 | |
| pharmgkb | rs1131341 |
| gwascentral | rs1131341 |
| openSNP | rs1131341 |
| 23andMe | rs1131341 |
| 23andMe all | rs1131341 |
| SNP Nexus | |
| SNPshot | rs1131341 |
| SNPdbe | rs1131341 |
| MSV3d | rs1131341 |
| Gene | NQO1 |
| Chromosome | 16 |
| Orientation | minus |
| GMAF | 0.0169 |
| Position | 69748869 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 0 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 |
| Make rs1131341(C;T) |
| Make rs1131341(T;T) |
rs1131341 (C465T, Arg139Trp) is a snp within NQO1 (NAD(P)H dehydrogenase (quinone 1)). A Trp (T) at this location denotes the NQO1*3 allele.
per [pharmgkb], the NQ1*3 allele is associated with reduced enzyme activity
[PMID 16266898] T allele strongly associated (OR = 6.36, CI = 1.84 - 21.90, p = 0.002) with infant acute lymphoblastic leukemia among 103 case infants and 185 controls
| ? | (C;C) (C;T) | |
|---|---|---|
[PMID 15576619] Hematotoxicity in workers exposed to low levels of benzene.
[PMID 17885617] Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.
[PMID 18547414] Genotyping panel for assessing response to cancer chemotherapy.
[PMID 18632753] Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.
[PMID 18922824] Genetic susceptibility to childhood leukaemia.
[PMID 18992148] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
[PMID 20663217] Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.
| GET Evidence | |
|---|---|
| NQO1-R139W | |
| aa_change | Arg139Trp |
| aa_change_short | R139W |
| impact | not reviewed |
| qualified_impact | Insufficiently evaluated not reviewed |
| overall_frequency | 0.0301171 |
| summary | |
