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Rs1131341

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Orientationplus
is asnp
is mentioned by
dbSNPrs1131341
PheGenIrs1131341
nextbiors1131341
hapmaprs1131341
1000 genomesrs1131341
hgdprs1131341
ensemblrs1131341
gopubmedrs1131341
geneviewrs1131341
scholarrs1131341
googlers1131341
pharmgkbrs1131341
gwascentralrs1131341
openSNPrs1131341
23andMers1131341
23andMe allrs1131341
SNP Nexus

SNPshotrs1131341
SNPdbers1131341
MSV3drs1131341
GeneNQO1
Chromosome16
Orientationplus
GMAF0.01699
Position69714966
ReferenceGRCh38 38.1/141
Max Magnitude0
Geno Mag Summary
(C;C) 0
Make rs1131341(C;T)
Make rs1131341(T;T)
rs1131341 (C465T, Arg139Trp) is a snp within NQO1 (NAD(P)H dehydrogenase (quinone 1)). A Trp (T) at this location denotes the NQO1*3 allele.

per [pharmgkb], the NQ1*3 allele is associated with reduced enzyme activity

[PMID 16266898] T allele strongly associated (OR = 6.36, CI = 1.84 - 21.90, p = 0.002) with infant acute lymphoblastic leukemia among 103 case infants and 185 controls


? (C;C) (C;T)
[PMID 15576619OA-icon.png] Hematotoxicity in workers exposed to low levels of benzene.


[PMID 17885617] Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.


[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.


[PMID 18632753OA-icon.png] Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.


[PMID 18922824OA-icon.png] Genetic susceptibility to childhood leukaemia.


[PMID 18992148OA-icon.png] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.


[PMID 20663217OA-icon.png] Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.


GET Evidence
NQO1-R139W
aa_change Arg139Trp
aa_change_short R139W
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0301171
summary



[PMID 23054000] Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India.


[PMID 23175176] Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.


[PMID 24830960] Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer