rs1128535

minus

Geno	Mag	Summary
(A;A)	0.5	normal
(A;G)	1.8	0.77x risk for Crohn's disease
(G;G)	2	reduced risk (0.77x) for Crohn's disease

Reference

GRCh38 38.1/141

Chromosome

3

Position

49828959

Gene

TRAIP

is a	snp
is	mentioned by
dbSNP	rs1128535
dbSNP (classic)	rs1128535
ClinGen	rs1128535
ebi	rs1128535
HLI	rs1128535
Exac	rs1128535
Gnomad	rs1128535
Varsome	rs1128535
LitVar	rs1128535
Map	rs1128535
PheGenI	rs1128535
Biobank	rs1128535
1000 genomes	rs1128535
hgdp	rs1128535
ensembl	rs1128535
geneview	rs1128535
scholar	rs1128535
google	rs1128535
pharmgkb	rs1128535
gwascentral	rs1128535
openSNP	rs1128535
23andMe	rs1128535
SNPshot	rs1128535
SNPdbe	rs1128535
MSV3d	rs1128535
GWAS Ctlg	rs1128535

GMAF

0.393

Max Magnitude

2

?

(A;A) (A;G) (G;G)

28

The less common allele of rs1128535, a SNP in the TRAIP gene, may have a protective effect against the development of Crohn's disease, based on a study of 469 Caucasian patients. The reported odds ratio is 0.77 (CI: 0.67-0.89, p=0.002).[PMID 18200509]

Note that rs1128535 is highly correlated (r² > 0.8) to nonsynonymous SNPs in the nearby MST1R gene, rs2230590 and rs1062633, also known as Arg523Gln and Gly1335Arg, respectively. [PMID 18200509]

[PMID 19657358] Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility