Rs1128503

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dbSNPrs1128503
hapmaprs1128503
hgdprs1128503
ensemblrs1128503
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hgvbaseg2prs1128503
medrefsnprs1128503
23andMers1128503
SNP Nexus

GeneABCB1
Chromosome7
Orientationminus
Position87017536
GenotypeEffect
rs1128503(C;C)normal
rs1128503(C;T)may require more methadone during heroin withdrawal
rs1128503(T;T)likely to require more methadone during heroin withdrawal


Genotypes Magnitude Summary
Rs1128503(C;C) 00 normal
Rs1128503(C;T) may require more methadone during heroin withdrawal
Rs1128503(T;T) likely to require more methadone during heroin withdrawal
rs1128503 is a SNP in the transporter P-glycoprotein (P-gp) 170, encoded by the ABCB1 (also known as MDR1) gene. Methadone is a substrate of this protein, so variants may affect the efficacy and optimal dosage of this drug as used for treating opiate dependence.

A study of 98 methadone-maintaining patients concluded that the higher (>150 mg/day) and lower (< or =150 mg/day) methadone dose groups differed significantly in their rs1128503 status (experiment-wise p = 0.0325). Furthermore, individuals with the 3-locus genotype pattern (T;T)-(T;T)-(T;T) for SNPs rs1045642, rs2032582 and rs1128503, respectively, had an approximately 5-fold chance of requiring the 'higher' methadone dose, while individuals heterozygous for these three SNPs have an approximately 3-fold chance of stabilizing at the 'lower' methadone dose (point-wise p-value = 0.026).[PMID 18424454]

? (C;C) (C;T) (T;T)
Neighborrs2235035
Distance515


[PMID 19107781] Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: a gene-wide study in a pediatric population

PharmGKBPA161145209
NameABCB1:1236C>T
AnnotationThis SNP is well known, but there is no clear consensus on its significance for drug disposition, response or toxicity.
GeneABCB1
FeatueExon/Syn
EvidenceWeb Resource:http://www.pharmgkb.org/search/annotatedGene/abcb1/variant.jsp#ImportantVariantInformationforABCB1-1236
Drugs
Diseases
Curation LevelIn-Depth


[PMID 19437139] ABCB1 single nucleotide polymorphisms in the Brazilian population