Rs1128503

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Orientationminus
Geno Mag Summary
(C;C) 0 normal
(C;T) may require more methadone during heroin withdrawal
(T;T) likely to require more methadone during heroin withdrawal
ReferenceGRCh38 38.1/141
Chromosome7
Position87550285
GeneABCB1
is asnp
is mentioned by
dbSNPrs1128503
PheGenIrs1128503
nextbiors1128503
hapmaprs1128503
1000 genomesrs1128503
hgdprs1128503
ensemblrs1128503
gopubmedrs1128503
geneviewrs1128503
scholarrs1128503
googlers1128503
pharmgkbrs1128503
gwascentralrs1128503
openSNPrs1128503
23andMers1128503
23andMe allrs1128503
SNP Nexus

SNPshotrs1128503
SNPdbers1128503
MSV3drs1128503
GMAF0.4219
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs1128503 is a SNP in the transporter P-glycoprotein (P-gp) 170, encoded by the ABCB1 (also known as MDR1) gene. Methadone is a substrate of this protein, so variants may affect the efficacy and optimal dosage of this drug as used for treating opiate dependence.

A study of 98 methadone-maintaining patients concluded that the higher (>150 mg/day) and lower (< or =150 mg/day) methadone dose groups differed significantly in their rs1128503 status (experiment-wise p = 0.0325). Furthermore, individuals with the 3-locus genotype pattern (T;T)-(T;T)-(T;T) for SNPs rs1045642, rs2032582 and rs1128503, respectively, had an approximately 5-fold chance of requiring the 'higher' methadone dose, while individuals heterozygous for these three SNPs have an approximately 3-fold chance of stabilizing at the 'lower' methadone dose (point-wise p-value = 0.026).[PMID 18424454OA-icon.png]

Neighborrs2235035
Distance515


[PMID 19107781] Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: a gene-wide study in a pediatric population



[PMID 19437139] ABCB1 single nucleotide polymorphisms in the Brazilian population






OMIM610064
Desc
Variant
Relatedalso


[PMID 21790905] CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction


[PMID 22015057] Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study


[PMID 22110582OA-icon.png] Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients


[PMID 21705081] Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma


[PMID 21806386] Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients


[PMID 22358301] ABCB1 genetic variation and P-glycoprotein expression/activity in a cohort of Brazilian acute myeloid leukemia patients


[PMID 22416375] [Genetic performance criteria valproate in patients with epilepsy]

[PMID 15197162OA-icon.png] Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene.

[PMID 16999857OA-icon.png] ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients.

[PMID 17548681] MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia.

[PMID 17913323] ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.

[PMID 18213362OA-icon.png] Multiplexed genotyping of ABC transporter polymorphisms with the Bioplex suspension array.

[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.

[PMID 18698231OA-icon.png] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

[PMID 18725235OA-icon.png] Bidirectional translational research: Progress in understanding addictive diseases.

[PMID 18812236] No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population.

[PMID 19155191OA-icon.png] Opiate and cocaine addiction: from bench to clinic and back to the bench.

[PMID 19285141OA-icon.png] Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response.

[PMID 19694740OA-icon.png] No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

[PMID 19740399OA-icon.png] Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant.

[PMID 19844206OA-icon.png] Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.

[PMID 20170205] Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I.

[PMID 20214406] Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II.

[PMID 20354687OA-icon.png] Explaining variability in ciclosporin exposure in adult kidney transplant recipients.

[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

[PMID 20533057OA-icon.png] ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer.

[PMID 21102498] Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21553324] Polymorphisms of the MDR1 and MIF genes in children with nephrotic syndrome.

[PMID 21840870] Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy.

[PMID 21896346] Polymorphisms in genes that regulate cyclosporine metabolism affect cyclosporine blood levels and clinical outcomes in patients who receive allogeneic hematopoietic stem cell transplantation.

[PMID 22134106] ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib.

[PMID 22136368] Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.

[PMID 22306099] Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population.

[PMID 22569204OA-icon.png] PharmGKB summary: phenytoin pathway.


GET Evidence
rs1128503
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.645566
summary



[PMID 23188198OA-icon.png] ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression


[PMID 23546964] Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant


[PMID 23093106] Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis


[PMID 23786015] [Pharmacogenetic criteria drug-resistence epilepsy]


[PMID 23917080] ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas


[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.


[PMID 23133441OA-icon.png] ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients.


[PMID 23443032] Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations.


[PMID 23462807OA-icon.png] Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib.


[PMID 23896815] Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury


[PMID 25007187] Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia