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From SNPedia

Geno Mag Summary
(C;C) 0 normal
(C;T) may require more methadone during heroin withdrawal
(T;T) likely to require more methadone during heroin withdrawal
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs1128503
23andMe allrs1128503
SNP Nexus

GWAS Ctlgrs1128503
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs1128503 is a SNP in the transporter P-glycoprotein (P-gp) 170, encoded by the ABCB1 (also known as MDR1) gene. Methadone is a substrate of this protein, so variants may affect the efficacy and optimal dosage of this drug as used for treating opiate dependence.

A study of 98 methadone-maintaining patients concluded that the higher (>150 mg/day) and lower (< or =150 mg/day) methadone dose groups differed significantly in their rs1128503 status (experiment-wise p = 0.0325). Furthermore, individuals with the 3-locus genotype pattern (T;T)-(T;T)-(T;T) for SNPs rs1045642, rs2032582 and rs1128503, respectively, had an approximately 5-fold chance of requiring the 'higher' methadone dose, while individuals heterozygous for these three SNPs have an approximately 3-fold chance of stabilizing at the 'lower' methadone dose (point-wise p-value = 0.026).[PMID 18424454OA-icon.png]


[PMID 19107781] Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: a gene-wide study in a pediatric population

[PMID 19437139] ABCB1 single nucleotide polymorphisms in the Brazilian population

[PMID 21790905OA-icon.png] CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction

[PMID 22015057] Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study

[PMID 22110582OA-icon.png] Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients

[PMID 21705081] Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma

[PMID 21806386] Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients

[PMID 22358301] ABCB1 genetic variation and P-glycoprotein expression/activity in a cohort of Brazilian acute myeloid leukemia patients

[PMID 22416375] [Genetic performance criteria valproate in patients with epilepsy]

[PMID 15197162OA-icon.png] Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene.

[PMID 16999857OA-icon.png] ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients.

[PMID 17548681] MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia.

[PMID 17913323] ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.

[PMID 18213362OA-icon.png] Multiplexed genotyping of ABC transporter polymorphisms with the Bioplex suspension array.

[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.

[PMID 18698231OA-icon.png] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

[PMID 18725235OA-icon.png] Bidirectional translational research: Progress in understanding addictive diseases.

[PMID 18812236] No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population.

[PMID 19155191OA-icon.png] Opiate and cocaine addiction: from bench to clinic and back to the bench.

[PMID 19285141OA-icon.png] Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response.

[PMID 19694740OA-icon.png] No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

[PMID 19740399OA-icon.png] Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant.

[PMID 19844206OA-icon.png] Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.

[PMID 20170205] Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I.

[PMID 20214406] Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II.

[PMID 20354687OA-icon.png] Explaining variability in ciclosporin exposure in adult kidney transplant recipients.

[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

[PMID 20533057OA-icon.png] ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer.

[PMID 21102498] Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21553324] Polymorphisms of the MDR1 and MIF genes in children with nephrotic syndrome.

[PMID 21840870] Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy.

[PMID 21896346] Polymorphisms in genes that regulate cyclosporine metabolism affect cyclosporine blood levels and clinical outcomes in patients who receive allogeneic hematopoietic stem cell transplantation.

[PMID 22134106] ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib.

[PMID 22136368] Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.

[PMID 22306099] Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population.

[PMID 22569204OA-icon.png] PharmGKB summary: phenytoin pathway.

GET Evidence
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.645566

[PMID 23188198OA-icon.png] ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression

[PMID 23546964] Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant

[PMID 23093106] Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis

[PMID 23786015] [Pharmacogenetic criteria drug-resistence epilepsy]

[PMID 23917080OA-icon.png] ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.

[PMID 23133441OA-icon.png] ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients.

[PMID 23443032OA-icon.png] Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations.

[PMID 23462807OA-icon.png] Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib.

[PMID 23896815OA-icon.png] Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury

[PMID 25007187] Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia

[PMID 25784996OA-icon.png] ABCB1 (rs1128503) polymorphism and response to chemotherapy in patients with malignant tumors-evidences from a meta-analysis

[PMID 26107754] Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation

[PMID 26107220] Quantitative Assessment of the Association between ABC Polymorphisms and Osteosarcoma Response: a Meta-analysis

[PMID 25355168] Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms

Risk rs1128503(C;C)
Alt rs1128503(C;C)
Reference rs1128503(T;T)
Significance Non-pathogenic
Disease not specified
Variation info
Gene ABCB1
CLNDBN not specified
Reversed 1
HGVS NC_000007.14:g.87550285A>G
CLNACC RCV000174498.1,