Rs11203366
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs11203366 |
| hapmap | rs11203366 |
| hgdp | rs11203366 |
| ensembl | rs11203366 |
| gopubmed | rs11203366 |
| scholar | rs11203366 |
| rs11203366 | |
| pharmgkb | rs11203366 |
| hgvbaseg2p | rs11203366 |
| medrefsnp | rs11203366 |
| 23andMe | rs11203366 |
| SNP Nexus |
| Gene | PADI4 |
| Chromosome | 1 |
| Orientation | plus |
| Position | 17657534 |
| Reference | GRCh37 37.1/131 |
| Genotype | Effect |
|---|---|
| rs11203366(A;A)* | ? |
| rs11203366(A;G)* | ? |
| rs11203366(G;G)* | ? |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| Venter snp | |
|---|---|
| Source | plos |
| Gene | PADI4 |
| allele | A |
| frequency | 0.417 |
| sift | TOLERATED |
| HuRef | 1103675033959 |
| Disease Association | PADI4 is thought to be a rheumatoid arthritis susceptibility locus (MIM:180300). Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context. |
| Neighbor | rs11203367 |
| Distance | 82 |
