Rs10995190

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Orientationplus
Make rs10995190(A;A)
Make rs10995190(A;G)
Make rs10995190(G;G)
ReferenceGRCh37 37.1/131
Chromosome10
Position64278682
GeneZNF365
is asnp
is mentioned by
dbSNPrs10995190
PheGenIrs10995190
nextbiors10995190
hapmaprs10995190
1000 genomesrs10995190
hgdprs10995190
ensemblrs10995190
gopubmedrs10995190
geneviewrs10995190
scholarrs10995190
googlers10995190
pharmgkbrs10995190
gwascentralrs10995190
openSNPrs10995190
23andMers10995190
23andMe allrs10995190
SNP Nexus

SNPshotrs10995190
SNPdbers10995190
MSV3drs10995190
GMAF0.1171
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 20453838OA-icon.png]
Trait Breast cancer
Title Genome-wide association study identifies five new breast cancer susceptibility loci
Risk Allele G
P-val 5E-15
Odds Ratio 1.16 [1.10-1.22]

23andMe blog each copy of an A at rs10995190 was associated with a 2% decrease in mammographic density. The researchers also found that each copy of an A at rs10995190 is also associated with slightly lower odds of developing breast cancer


[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies

GWAS snp
PMID [PMID 21278746OA-icon.png]
Trait
Title Common variants in ZNF365 are associated with both mammographic density and breast cancer risk
Risk Allele A
P-val 1E-9
Odds Ratio 0.1800 [0.12-0.25] % decrease


[PMID 22348646OA-icon.png] Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers


[PMID 22461340OA-icon.png] 11q13 is a susceptibility locus for hormone receptor positive breast cancer

Breast Cancer Risk Modifiers

GWAS snp
PMID [PMID 23535733OA-icon.png]
Trait Breast cancer
Title Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Risk Allele G
P-val 1E-7
Odds Ratio 1.12 [1.08-1.18]
GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele G
P-val 1E-36
Odds Ratio 1.16 [1.14-1.19]