Rs10984447

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Orientationplus
is asnp
is mentioned by
dbSNPrs10984447
PheGenIrs10984447
nextbiors10984447
hapmaprs10984447
1000 genomesrs10984447
hgdprs10984447
ensemblrs10984447
gopubmedrs10984447
geneviewrs10984447
scholarrs10984447
googlers10984447
pharmgkbrs10984447
gwascentralrs10984447
openSNPrs10984447
23andMers10984447
23andMe allrs10984447
SNP Nexus

SNPshotrs10984447
SNPdbers10984447
MSV3drs10984447
GeneBRINP1
Chromosome9
Orientationplus
GMAF0.1657
Position119222275
ReferenceGRCh38 38.1/141
Max Magnitude2
Geno Mag Summary
(A;A) 2 >1.17x increased risk for multiple sclerosis
(A;G) 2 1.17x increased risk for multiple sclerosis
(G;G) 1 Normal risk for multiple sclerosis
? (A;A) (A;G) (G;G) 28
rs10984447 has been reported in a large study to be associated with multiple sclerosis.

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with this allele is 1.17 (CI 1.09-1.25). [PMID 17660530]

GWAS
SNP rs10984447
PubMedID [PMID 17660530]
Condition Multiple sclerosis
Gene DBC1
Risk Allele A
pValue 8.00E-006
OR 1.17
95% CI 1.09-1.25




GET Evidence
rs10984447
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.179688
summary



[PMID 22492128] Association of SNPs rs6498169 and rs10984447 with multiple sclerosis in Saudi patients: a model of the usefulness of familial aggregates in identifying genetic linkage in a multifactorial disease.