From SNPedia
| Rs10946398
|
| PubMed
| [PMID 17463249]
|
| Affy Probeset
| SNP_A-4253796
|
| Affy Orientation
| reverse
|
| On GW 5.0
| 1
|
| Alleles A/B
| G/T
|
| Ancestral
| C
|
| Population
| EU (UK)
|
| Allele
| C
|
| Case Freq.
|
|
| Control Freq.
|
|
| Odds Ratio Het
|
|
| Odds Ratio Hom
|
|
| Odds Ratio All
| 1.14
|
| Disease
| Type II Diabetes (T2D)
|
| ? | (A;A) (A;C) (C;C) |
|---|
 |
rs10946398 increases susceptibility to Type II Diabetes 1.14 times for carriers of the C allele [PMID 17463249]
| GWAS snp
|
| PMID
| [PMID 19056611]
|
| Trait
| Type 2 diabetes
|
| Title
| Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
|
| Risk Allele
|
|
| P-val
| 7E-7
|
| Odds Ratio
| 1.18 [1.11-1.26]
|
Related to CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1-LIKE 1; CDKAL1
according to
omim 611259. See
also
| PharmGKB | PA162191334 |
| Name | |
| Annotation | rs10946398 is associated with susceptibility to Type 2 Diabetes. This association was identified in a UK case-control study and was replicated in another UK case-control cohort as well as in two other large case-control studies. |
| Gene | CDKAL1 |
| Featue | |
| Evidence | PubMed ID:17463249 |
| Drugs | |
| Diseases | Diabetes Mellitus, Type 2 |
| Curation Level | Curated |
