Rs10895068
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs10895068 |
| hapmap | rs10895068 |
| hgdp | rs10895068 |
| ensembl | rs10895068 |
| gopubmed | rs10895068 |
| scholar | rs10895068 |
| rs10895068 | |
| pharmgkb | rs10895068 |
| hgvbaseg2p | rs10895068 |
| medrefsnp | rs10895068 |
| 23andMe | rs10895068 |
| SNP Nexus |
| Chromosome | 11 |
| Orientation | minus |
| Position | 100505423 |
| Genotype | Effect |
|---|---|
| rs10895068(A;A) | 2.5x increased odds of breast cancer among hormone-using postmenopausal women |
| rs10895068(A;G) | 2.5x increased odds of breast cancer among hormone-using postmenopausal women |
| rs10895068(G;G) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs10895068(A;A) | 1.51.5 | 2.5x increased odds of breast cancer among hormone-using postmenopausal women |
| Rs10895068(A;G) | 1.51.5 | 2.5x increased odds of breast cancer among hormone-using postmenopausal women |
| Rs10895068(G;G) | normal |
A study of 1,664 postmenopausal breast cancer cases and 2,391 controls led to two conclusions. First, women with at least one rs10895068(A) allele had a 1.3x (CI: 1.04-1.65) increased risk of developing breast cancer. Second, such carriers were at 2.57x (CI: 1.64-4.02) increased risk for breast cancer if they became postmenopausal hormone users.[PMID 19462450]
[PMID 20076999] No association between a progesterone receptor gene promoter polymorphism (+331G>A) and breast cancer risk in Caucasian women: evidence from a literature-based meta-analysis
| ? | (A;A) (A;G) (G;G) |
|---|---|
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