Rs10835638

From SNPedia
Jump to: navigation, search

Orientationplus
Geno Mag Summary
(G;G) 0 common
(G;T) intermediate serum FSH level among males
(T;T) lower serum FSH level among males
ReferenceGRCh38 38.1/141
Chromosome11
Position30230805
GeneFSHB
is asnp
is mentioned by
dbSNPrs10835638
Exacrs10835638
PheGenIrs10835638
nextbiors10835638
hapmaprs10835638
1000 genomesrs10835638
hgdprs10835638
ensemblrs10835638
gopubmedrs10835638
geneviewrs10835638
scholarrs10835638
googlers10835638
pharmgkbrs10835638
gwascentralrs10835638
openSNPrs10835638
23andMers10835638
23andMe allrs10835638
SNP Nexus

SNPshotrs10835638
SNPdbers10835638
MSV3drs10835638
GMAF0.08632
rs10835638, a SNP located in the (upstream) regulatory region of the follicle stimulating hormone FSHB gene, may influence hormone levels.

A quantitative genetic association study of 550+ healthy Estonian men (average age 19) found that rs10835638 was significantly associated with serum FSH level (analysis of variance: F = 13.0, P = 0.0016, df = 1; regression testing for a linear trend: P = 0.0003).

Subjects with the (G;G) genotype had higher FSH levels (3.37 +/- 1.79 IU/l, n = 423) compared with (G;T) heterozygotes (2.84 +/- 1.54 IU/l, n = 125) (p = 0.0005) or (T;T) homozygotes (2.02 +/- 0.81 IU/L, n = 6) (P = 0.031). rs10835638 was also associated with significant reduction in free testosterone index and testes volume, but increased semen volume, sex hormone-binding globulin, serum testosterone and estradiol LH and inhibin-B levels did not differ significantly between groups.[PMID 18567894OA-icon.png]

[PMID 19897680OA-icon.png] Increased Prevalance of the -211 T Allele of Follicle Stimulating Hormone (FSH) {beta} Subunit Promoter Polymorphism and Lower Serum FSH in Infertile Men


[PMID 22791757] Combined Effects of the Variants FSHB -211G/T and FSHR 2039A>G on Male Reproductive Parameters


[PMID 23118424] Effects of the FSH-β-Subunit Promoter Polymorphism -211G->T on the Hypothalamic-Pituitary-Ovarian Axis in Normally Cycling Women Indicate a Gender-Specific Regulation of Gonadotropin Secretion


[PMID 25052309] The FSHB -211G>T variant attenuates serum FSH levels in the supraphysiological gonadotropin setting of Klinefelter syndrome