| Geno
|
Mag
|
Summary
|
| (G;G)
|
0
|
common
|
| (G;T)
|
|
intermediate serum FSH level among males
|
| (T;T)
|
|
lower serum FSH level among males
|
rs10835638, a SNP located in the (upstream) regulatory region of the follicle stimulating hormone FSHB gene, may influence hormone levels.
A quantitative genetic association study of 550+ healthy Estonian men (average age 19) found that rs10835638 was significantly associated with serum FSH level (analysis of variance: F = 13.0, P = 0.0016, df = 1; regression testing for a linear trend: P = 0.0003).
Subjects with the (G;G) genotype had higher FSH levels (3.37 +/- 1.79 IU/l, n = 423) compared with (G;T) heterozygotes (2.84 +/- 1.54 IU/l, n = 125) (p = 0.0005) or (T;T) homozygotes (2.02 +/- 0.81 IU/L, n = 6) (P = 0.031). rs10835638 was also associated with significant reduction in free testosterone index and testes volume, but increased semen volume, sex hormone-binding globulin, serum testosterone and estradiol LH and inhibin-B levels did not differ significantly between groups.[PMID 18567894]
[PMID 19897680] Increased Prevalance of the -211 T Allele of Follicle Stimulating Hormone (FSH) {beta} Subunit Promoter Polymorphism and Lower Serum FSH in Infertile Men
[PMID 22791757] Combined Effects of the Variants FSHB -211G/T and FSHR 2039A>G on Male Reproductive Parameters
[PMID 23118424] Effects of the FSH-β-Subunit Promoter Polymorphism -211G->T on the Hypothalamic-Pituitary-Ovarian Axis in Normally Cycling Women Indicate a Gender-Specific Regulation of Gonadotropin Secretion
