Rs10821936

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Orientationplus
is asnp
is mentioned by
dbSNPrs10821936
PheGenIrs10821936
nextbiors10821936
hapmaprs10821936
1000 genomesrs10821936
hgdprs10821936
ensemblrs10821936
gopubmedrs10821936
geneviewrs10821936
scholarrs10821936
googlers10821936
pharmgkbrs10821936
gwascentralrs10821936
openSNPrs10821936
23andMers10821936
23andMe allrs10821936
SNP Nexus

SNPshotrs10821936
SNPdbers10821936
MSV3drs10821936
GeneARID5B
Chromosome10
Orientationplus
GMAF0.3108
Position63723577
ReferenceGRCh37 37.1/131
Max Magnitude
Make rs10821936(C;C)
Make rs10821936(C;T)
Make rs10821936(T;T)
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19684603OA-icon.png]
Trait Acute lymphoblastic leukemia (childhood)
Title Germline genomic variants associated with childhood acute lymphoblastic leukemia
Risk Allele C
P-val 1E-15
Odds Ratio 1.91 [1.60-2.20]



OMIM613065
Desc
Variant
Relatedalso
[PMID 22291082OA-icon.png] ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia


[PMID 22422485OA-icon.png] Genetic variants modify susceptibility to leukemia in infants: A Children's Oncology Group report


[PMID 20460642OA-icon.png] Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia.


GET Evidence
rs10821936
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.6875
summary



[PMID 23608171] Association of three polymorphisms in ARID5B, IKZF1and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population

GWAS snp
PMID [PMID 23512250]
Trait Acute lymphoblastic leukemia (childhood)
Title Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
Risk Allele C
P-val 6E-46
Odds Ratio 1.86 [1.71-2.03]


[PMID 23692655] ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group


[PMID 24564228] ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia