From SNPedia
| ? | (A;A) (A;C) (C;C) |
|---|
 |
is located in intron 6 of the dopamine receptor D2 gene.
In one study of Japanese males, rs1076560(A) alleles were 1.3 fold more associated with Alcoholism than the rs1076560(C) alleles. [PMID 17196743]
The DRD2 risk allele A was more prevalent in the alcoholic patients than in the healthy controls. These data identify rs1076560 as a potentially important variable in the development of alcoholism.
[PMID 19176830] rs1076560 and the DAT 3'-VNTR variant influences memory
[PMID 19373123] Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution
[PMID 19796663] Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients
[PMID 19940176] Functional Variation of the Dopamine D2 Receptor Gene Is Associated with Emotional Control as well as Brain Activity and Connectivity during Emotion Processing in Humans
| PharmGKB | PA162355758 |
| Name | |
| Annotation | This variant is in intron 6, and T allele shifts mRNA splicing from the short form (D2S) to the long form (D2L). The T allele carriers are also associated with reduced working memory and attension perfermance. |
| Gene | DRD2 |
| Featue | |
| Evidence | PubMed ID:18077375; PubMed ID:18829695 |
| Drugs | |
| Diseases | Schizophrenia |
| Curation Level | Curated |
[PMID 19512960] Genetic diagnostics of functional variants of the human dopamine D2 receptor gene
[PMID 20179754] Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance
