Rs1076560
| is a | snp |
| is | mentioned by |
| dbSNP | rs1076560 |
| nextbio | rs1076560 |
| hapmap | rs1076560 |
| 1000 genomes | rs1076560 |
| hgdp | rs1076560 |
| ensembl | rs1076560 |
| gopubmed | rs1076560 |
| scholar | rs1076560 |
| rs1076560 | |
| pharmgkb | rs1076560 |
| gwascentral | rs1076560 |
| openSNP | rs1076560 |
| 23andMe | rs1076560 |
| 23andMe all | rs1076560 |
| SNP Nexus | |
| SNPshot | rs1076560 |
| SNPdbe | rs1076560 |
| MSV3d | rs1076560 |
| Gene | DRD2 |
| Chromosome | 11 |
| Orientation | plus |
| Position | 113283688 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 2 |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2 | influences working memory |
| (A;C) | 1.3x increased risk for alcoholism | |
| (C;C) | 0 | normal |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
| Neighbor | rs1801028 |
| Distance | 204 |
| Neighbor | rs1800496 |
| Distance | 200 |
In one study of Japanese males, rs1076560(A) alleles were 1.3 fold more associated with Alcoholism than the rs1076560(C) alleles. [PMID 17196743]
The DRD2 risk allele A was more prevalent in the alcoholic patients than in the healthy controls. These data identify rs1076560 as a potentially important variable in the development of alcoholism.
[PMID 19176830] rs1076560 and the DAT 3'-VNTR variant influences memory
[PMID 19373123] Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution
[PMID 19796663] Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients
[PMID 19940176] Functional Variation of the Dopamine D2 Receptor Gene Is Associated with Emotional Control as well as Brain Activity and Connectivity during Emotion Processing in Humans
| PharmGKB | PA162360621 |
| Name | |
| Annotation | This variant is a potential marker for alcoholism. A allele was more prevalent in the alcoholic patients than in the healthy controls in a study consists of 248 alcoholic patients and 322 healthy controls (all Japanese males). |
| Gene | DRD2 |
| Featue | |
| Evidence | PubMed ID:17196743 |
| Drugs | ethanol |
| Diseases | Alcoholism |
| Curation Level | Curated |
[PMID 19512960] Genetic diagnostics of functional variants of the human dopamine D2 receptor gene
[PMID 20179754] Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance
[PMID 19393722] Genetic contributions to avoidance-based decisions: striatal D2 polymorphisms
| PharmGKB | PA162355758 |
| Name | |
| Annotation | This variant is in intron 6, and T allele shifts mRNA splicing from the short form (D2S) to the long form (D2L). The T allele carriers are also associated with reduced working memory and attension perfermance. |
| Gene | DRD2 |
| Featue | |
| Evidence | PubMed ID:18077375; PubMed ID:18829695 |
| Drugs | |
| Diseases | Schizophrenia |
| Curation Level | Curated |
[PMID 21087673] D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans
[PMID 21150907] Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.
[PMID 22569179] Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese
