| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
|
| (C;C)
|
|
1.16x increased risk for breast cancer
|
| (C;T)
|
|
1.08x increased risk for breast cancer
|
| (T;T)
|
|
normal risk
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
[
PMID 18056155]
breast cancer rs1061646 was associated with risk in the initial study (p=0.0052), and in the replication studies (p=0.032). In a combined analysis, (8,556 cases, 9,605 controls) this SNP yielded an 8% increase in risk per allele. Note that this analysis was carried out in a multi-ethnic study, and
rs1061646 showed more consistent association with risk in non-Caucasian populations.
[PMID 18701435] Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.
