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Rs1061646

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Orientationminus
is asnp
is mentioned by
dbSNPrs1061646
PheGenIrs1061646
nextbiors1061646
hapmaprs1061646
1000 genomesrs1061646
hgdprs1061646
ensemblrs1061646
gopubmedrs1061646
geneviewrs1061646
scholarrs1061646
googlers1061646
pharmgkbrs1061646
gwascentralrs1061646
openSNPrs1061646
23andMers1061646
23andMe allrs1061646
SNP Nexus

SNPshotrs1061646
SNPdbers1061646
MSV3drs1061646
GeneFANCA, ZNF276
Chromosome16
Orientationminus
GMAF0.4775
Position89739569
ReferenceGRCh38 38.1/141
Max Magnitude0
Geno Mag Summary
(A;A) 0
(C;C) 1.16x increased risk for breast cancer
(C;T) 1.08x increased risk for breast cancer
(T;T) normal risk
? (C;C) (C;T) (T;T) 28
[PMID 18056155] breast cancer rs1061646 was associated with risk in the initial study (p=0.0052), and in the replication studies (p=0.032). In a combined analysis, (8,556 cases, 9,605 controls) this SNP yielded an 8% increase in risk per allele. Note that this analysis was carried out in a multi-ethnic study, and rs1061646 showed more consistent association with risk in non-Caucasian populations.


[PMID 18701435OA-icon.png] Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.