Rs10515860

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Orientationplus
Geno Mag Summary
(G;G) 0 common in complete genomics
Make rs10515860(A;A)
Make rs10515860(A;G)
ReferenceGRCh38 38.1/141
Chromosome5
Position163490702
GeneHMMR, HMMR-AS1
is asnp
is mentioned by
dbSNPrs10515860
PheGenIrs10515860
nextbiors10515860
hapmaprs10515860
1000 genomesrs10515860
hgdprs10515860
ensemblrs10515860
gopubmedrs10515860
geneviewrs10515860
scholarrs10515860
googlers10515860
pharmgkbrs10515860
gwascentralrs10515860
openSNPrs10515860
23andMers10515860
23andMe allrs10515860
SNP Nexus

SNPshotrs10515860
SNPdbers10515860
MSV3drs10515860
GMAF0.07071
Max Magnitude0
? (A;A) (A;G) (G;G) 28

cancergenetics The risk of breast cancer was 23% higher in women who had one copy of genetic variant (the A-C-A haplotype: rs7712023-rs299290-rs10515860), and 46% higher in women with two copies. In addition, those women were diagnosed an average of 12 months younger than women from the control group, suggesting that HMMR is linked to early-onset breast cancer.

However, a more recent, larger European case-control study found no association between rs10515860 and risk of breast cancer.[PMID 19065580]

[PMID 19064580] breast cancer

  • rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9],
  • rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7],
  • rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1],
  • rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and *rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].